Bob DeMarco Alzheimer's Reading Room

Tuesday, May 29, 2007

Immune Antibodies Penetrate Neurons to Clear Alzheimer's-Linked Amyloid



Discovery Could Advance Treatment for Alzheimer's, Immune Diseases, Weill Cornell Team Says

Researchers at Weill Cornell Medical College have gotten much closer to understanding how immune-based therapies can treat Alzheimer's disease — by studying how antibodies go inside brain cells to reduce levels of Alzheimer's-linked amyloid peptides that form plaques between neurons.

"This internalization and activity of the antibody within the cell was a big surprise and something we really haven't appreciated in neurological medicine. It gives us new hope for the use of immunotherapy against Alzheimer's, while casting intriguing new light on other disease processes," says senior author Dr. Gunnar Gouras, associate professor of neurology and neuroscience at Weill Cornell Medical College and associate attending neurologist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

His team's study will appear as a prestigious "paper of the week" in an upcoming issue of the Journal of Biological Chemistry, and was published in the May 1 online edition of the journal.

Read the original source material and the article in its entirity at the Weill Cornell Medical W

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Bob DeMarco is the editor of the Alzheimer's Reading Room and an Alzheimer's caregiver. The Alzheimer's Reading Room is the number one website on the Internet for news, advice, and insight into Alzheimer's disease. Bob has written more than 950 articles with more than 8,000 links on the Internet. Bob resides in Delray Beach, FL.

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