Sometimes it's better if great minds don't think alike. Neurobiologists with decidedly different interests recently collaborated at Northwestern University and came up with new evidence about Alzheimer's disease, a form of dementia that affects about 5 million Americans. They now consider it a Type 3 diabetes.
This team studied healthy nerve cells from the brain's hippocampus region, growing in culture dishes, and they observed abundant insulin receptors. "If you look closely at a high-resolution [image], you'll see that they are at synapses," Klein said. "Before we added the ADDLs [toxins], they all had insulin receptors." But with the toxin added to the culture dishes, "the insulin receptors disappeared from their surfaces."
"[Klein's work] is like finding the missing piece of a jigsaw puzzle,"
"[Researchers] are looking at drugs that are given to Type 2 diabetics that increase the ability of cells to respond to insulin. It makes the insulin receptors more abundant or more lively."
Wednesday, November 28, 2007
Researchers deem Alzheimer's a Type 3 diabetes
My grandmother was diabetic, my sister is diabetic and my mother suffers from Alzheimer's.