Bob DeMarco Alzheimer's Reading Room

Sunday, October 25, 2009

What is Rember?


The Alzheimer's Reading Room receives visitors to this site every day from people that are searching the Google key word -- Rember.

What is Rember?

Bob DeMarco
Alzheimer's Reading Room

Rember is supposedly a new version of an existing chemical substance, methylene blue, but modified to be used as a drug for the treatment and prevention of Alzheimer’s.

The news on Rember was released at the International Conference on Alzheimer's Disease (ICAD) in 2008. It created a tidal wave of press and news on television when the company made this claim:
Research findings point to a new treatment that appears to slow the progress of Alzheimer's by 81% over a year. The product - Rember - is the first drug to act to arrest the progression of Alzheimer's disease by targeting the tangles which are highly correlated with the disease.
The buzz in the world of Alzheimer's was tremendous.

Remember this news was released as part of a presentation by TauRx Therapeutics Ltd at the annual conference on Alzheimer's disease sponsored by the Alzheimer's Association (ICAD, 2008).

What happened next? Nothing, absolutely nothing.

A look at the TauRX website shows that there has not been a single new news release on the company website since July, 2008. There is no existing news about the companies clinical trials.

Is the search for the holy grail of Alzheimer's disease over? Was this a hoax perpetrated on the Alzheimer's Association and the public?

I should also note that the chemical MTC has been used in the past to treat urinary tract infections and other conditions. The compound methylene blue is easy to obtain and is currently available for purchase.

Also see: Rember (Methylene Blue) For Alzheimer's, the Hype Continues.

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Here Is what I wrote about the presentation back in 2008.

What is rember and how is it supposed to work?

Rember is a new version of an existing chemical substance, but modified to be used as a drug for the treatment and prevention of Alzheimer’s. The chemical, called MTC, has been used in the past to treat urinary tract infections and other conditions.

TauRx Therapeutics Ltd claims that rember acts by 'disrupting and dissolving' the abnormal build-up of Tau protein in brain cells, thus breaking down (and possibly preventing) tangles.

How is rember different from existing drugs for Alzheimer's disease?

Existing drugs for Alzheimer's disease, such as Aricept (and Namenda), work to lessen the symptoms of the illness. However, these drugs do not stop the death of the nerve cells in the long run. Aricept is a treament for Alzheimer's, not a cure.

It is claimed that rember could prevent the death of nerve cells.

Is rember a cure for Alzheimer's Disease?

While the results are very promising, it is important to consider the following:
these results are from a trial of 321 people, from Aberdeen, Birmingham and Singapore, over a period of less than 2 years (note : an open label study with these patients is on-going), a Phase 3 trial is necessary to determine whether the drug will be well tolerated and show continued effectiveness, the findings of the Phase 2 trial are yet to be published in an academic journal.

Can I get rember from my family physician?

No. The drug is still in clinical trials and there are no licensing arrangements in place for the existing drug.

Can I buy rember over the internet?

It can be extremely dangerous to buy any drug over the internet or from other sources. Rember is still being developed and tested, this potential treatment for Alzheimer's disease cannot be purchased online.

How can I get involved in the rember Phase 3 trial?

Right now the Phase 3 clinical trial has not been scheduled. We will continue to monitor the situation at the Alzheimer's Reading Room and keep you posted.

TauRx Therapeutics Ltd

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Bob DeMarco is the editor of the Alzheimer's Reading Room and an Alzheimer's caregiver. The Alzheimer's Reading Room is the number one website on the Internet for news, advice, and insight into Alzheimer's disease. Bob has written more than 800 articles with more than 18,000 links on the Internet. Bob resides in Delray Beach, FL.

Original content Bob DeMarco, Alzheimer's Reading Room