An extract found in cinnamon bark, called CEppt, contains properties that can inhibit the development of Alzheimer's disease, according to Prof. Michael Ovadia of the Department of Zoology at Tel Aviv University.
Did you know? Cinnamon was kept with other potion ingredients in the Potions Classroom at Hogwarts School of Witchcraft and Wizardry.
Bob De Marco +Alzheimer's Reading Room
I am extremely interested in this medical science. I shake cinnamon in my coffee every morning and use it whenever I can. Yawning yet?
Consider, I rarely get sick. I am remembering back to when I needed a hernia operation. The doctor looked in my file and said, "the only thing you have been in here for in seven years is a physical." He was amazed and so was I. My file was as thin and as thin could be.
Since I arrived in Florida to take of my mother I have been sick a total of two days. I actually caught something from an elderly friend of my mother who spent three weeks in a hospital due to his infection.
I took an over the counter medication and was better in three days.
Was it the cinnamon? Did cinnamon bring me good luck (;>). Who knows? We will see what the future brings for me.
I have not taken an antibiotic in at least 15 years.
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Alzheimer's prevention in your pantry
Alzheimer's, the degenerative brain disorder that disrupts memory, thought and behavior, is devastating to both patients and loved ones. According to the Alzheimer's Association, one in eight Americans over the age of 65 suffers from the disease. Now Tel Aviv University has discovered that an everyday spice in your kitchen cupboard could hold the key to Alzheimer's prevention.
An extract found in cinnamon bark, called CEppt, contains properties that can inhibit the development of the disease, according to Prof. Michael Ovadia of the Department of Zoology at Tel Aviv University. His research, conducted in collaboration with Prof. Ehud Gazit, Prof. Daniel Segal and Dr. Dan Frenkel, was recently published in the journal PLoS ONE.
Taking a cue from the ancient world
Prof. Ovadia was inspired to investigate the healing properties of cinnamon by a passage in the Bible. It describes high priests using the spice in a holy ointment, he explains, presumably meant to protect them from infectious diseases during sacrifices. After discovering that the cinnamon extract had antiviral properties, Prof. Ovadia empirically tested these properties in both laboratory and animal Alzheimer's models.
The researchers isolated CEppt by grinding cinnamon and extracting the substance into an aqueous buffer solution. They then introduced this solution into the drinking water of mice that had been genetically altered to develop an aggressive form of Alzheimer's disease, and fruit flies that had been mutated with a human gene that also stimulated Alzheimer's disease and shortened their lifespan.
After four months, the researchers discovered that development of the disease had slowed remarkably and the animals' activity levels and longevity were comparable to that of their healthy counterparts. The extract, explains Prof. Ovadia, inhibited the formation of toxic amyloid polypeptide oligomers and fibrils, which compose deposits of plaque found in the brains of Alzheimer's patients.
In the test-tube model, the substance was also found to break up amyloid fibers, similar to those collected in the brain to kill neurons. According to Prof. Ovadia, this finding indicates that CEppt may not just fight against the development of the disease, but may help to cure it after Alzheimer's molecules have already formed. In the future, he says, the team of researchers should work towards achieving the same result in animal models.
Adding a dash of cinnamon
Don't rush to your spice cabinet just yet, however. It would take far more than a toxic level of the spice — more than 10 grams of raw cinnamon a day — to reap the therapeutic benefits. The solution to this medical catch-22, Prof. Ovadia says, would be to extract the active substance from cinnamon, separating it from the toxic elements.
"The discovery is extremely exciting. While there are companies developing synthetic AD inhibiting substances, our extract would not be a drug with side effects, but a safe, natural substance that human beings have been consuming for millennia," says Prof. Ovadia.
Though it can't yet be used to fight Alzheimer's, cinnamon still has its therapeutic benefits — it can also prevent viral infections when sprinkled into your morning tea.
American Friends of Tel Aviv University (www.aftau.org) supports Israel's leading, most comprehensive and most sought-after center of higher learning. Independently ranked 94th among the world's top universities for the impact of its research, TAU's innovations and discoveries are cited more often by the global scientific community than all but 10 other universities.
Internationally recognized for the scope and groundbreaking nature of its research and scholarship, Tel Aviv University consistently produces work with profound implications for the future.
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- About the Alzheimer's Reading Room
Alzheimer's Reading Room and an Alzheimer's caregiver. The blog contains more than 3,360 articles with more than 402,100 links on the Internet. Bob lives in Delray Beach, FL.
Original content Bob DeMarco, the Alzheimer's Reading Room