Aug 11, 2013

Exercise May Help Prevent Brain Damage Caused by Alzheimer's Disease

This elegant series of experiments reveals an alternative pathway by which voluntary physical exercise may protect hippocampal neurons.

By Bob DeMarco
+Alzheimer's Reading Room

Dorothy DeMarco

This research, and the growing body of evidence about exercise and Alzheimer's disease, catches my attention.

In our case, even after Dotty was diganosed with probable Alzheimer's I started taking her into the gym for "real" exercise. Dotty was 87 years old when she went to a gym for the first time in her life.

Prior to going to the gym, Dotty was often dull and "not really there". Sometimes it was like she was crawling just to get into the gym. Prior to the gym her behavior was horrible.

On the way out of the gym, Dotty was standing taller, she had a smile on her face, and she was clearly "more there" and cooperative. Every single time.

No doubt the exercise helped Dotty. I also think the sense of accomplishment had a positive affect on her demeanor.

I know a lot of people will comment that so and so exercised their entire life and still ended up with Alzheimer's disease.

The issue here, do lifestyle choices make a difference? I believe they do.

Just so you know, almost everyone that writes to me to tell me they are doing well has exercise as a part of their daily regimen.


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Exercise may help prevent brain damage caused by Alzheimer's disease

Regular exercise could help prevent brain damage associated with neurodegenerative diseases like Alzheimer's, according to research published  in journal Brain, Behavior, and Immunity.

"Exercise allows the brain to rapidly produce chemicals that prevent damaging inflammation", said Professor Jean Harry, who led the study at the National Institute of Environmental Health Sciences in the United States. "This could help us develop a therapeutic approach for early intervention in preventing damage to the brain."

Previous research has already demonstrated that exercise after brain injury can help the repair mechanisms.

This new study shows that exercise before the onset of damage modifies the brain environment in such a way that the neurons are protected from severe insults.

The study used an experimental model of brain damage, in which mice are exposed to a chemical that destroys the hippocampus, an area of the brain which controls learning and memory. Mice that were exercised regularly prior to exposure produced an immune messenger called interleukin-6 in the brain, which dampens the harmful inflammatory response to this damage, and prevents the loss of function that is usually observed.

Pharmacological therapies to downregulate inflammation and address cognitive decline in older adults, and those with Alzheimer's disease, have been less successful.

This research helps understand how exercise could be used to affect the path of many human conditions, such as neurodevelopmental disorders and neurodegenerative diseases. In addition, as a chemical model of neuronal damage was used, it also raises the possibility that exercise could offer protection against the potentially harmful effects of environmental toxins.
"This elegant series of experiments reveals an alternative pathway by which voluntary physical exercise may protect hippocampal neurons", said Dr. Ruth Barrientos from the Department of Psychology and Neuroscience at the University of Colorado.

"The study on the role of exercise as a therapeutic intervention will undoubtedly get a workout in the years to come. Perhaps the greatest challenge with this line of research will not be more discoveries of compelling evidence of the anti-neuroinflammatory effects of exercise, but instead, getting humans to exercise voluntarily and regularly."
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The research was funded by the Division of Intramural Research, National Institute of Environmental Health Sciences, and the National Institutes of Health.

The article is "Voluntary exercise protects hippocampal neurons from trimethyltin injury: Possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity" by Jason A. Funk, Julia Gohlke, Andrew D. Kraft, Christopher A. McPherson and Jennifer B. Collins. The article appears in Brain, Behavior, and Immunity, Volume 25, Number 6 (August 2011), published by Elsevier.

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Original content +Bob DeMarco , the Alzheimer's Reading Room