The ability to detect or exclude significant amyloid deposits in the brain, along with other diagnostic tests, may help physicians make a more accurate assessment of patients with suspected Alzheimer’s disease and other cognitive disorders.
One study, in terminally ill patients who agreed to undergo brain autopsy, showed strong concordance between flutemetamol PET images and Alzheimer’s disease-associated beta amyloid brain pathology.
The other study, in young healthy volunteers under age 40, had results concordant with the known lack of brain amyloid in this population.
Full results of these studies will be presented in the coming months. [18F]Flutemetamol is a GE Healthcare PET imaging agent in development for the detection of beta amyloid.
|Subscribe to the Alzheimer's Reading Room|
“The ability to detect or exclude significant amyloid deposits in the brain, along with other diagnostic tests, may help physicians make a more accurate assessment of patients with suspected Alzheimer’s disease and other cognitive disorders. The results from these studies are quite encouraging in demonstrating the potential of flutemetamol in that regard,” said Carl Sadowsky, MD, Clinical Professor of Neurology at Nova Southeastern University Ft. Lauderdale, FL. “We need an accurate diagnosis and better treatment, as accurate diagnosis has the potential to enable better patient management, and may also save cost.”The accumulation of beta amyloid in the brain is believed to play a role leading up to the degeneration of neurons in Alzheimer’s disease (AD) and is one of several pathological characteristics implicated in the development of AD. Currently, AD is confirmed by histopathological identification of core features, including beta amyloid plaques, in post-mortem brain samples.[i] Targeted amyloid imaging agents are being studied to determine their ability to help physicians detect amyloid deposition in living humans.
“Flutemetamol may well prove to be a clinically valuable component of a broader diagnostic workup that neurologists use when assessing patients with cognitive impairments, who may have AD,” said Jonathan Allis, MI PET Segment Leader, GE Healthcare Medical Diagnostics. “These studies support our application for regulatory approval of [18F]flutemetamol, and we intend to file later this year.”
[18F]Flutemetamol is one component of a broad portfolio of diagnostic solutions that GE Healthcare is currently developing in the Alzheimer’s field. GE Healthcare is taking a comprehensive approach to understanding AD through its ongoing research to uncover the causes, risks and physical effects of the disease. For example, the company is partnering with pharma to identify a biosignature, or a biological indicator, which may help physicians diagnose Alzheimer’s disease prior to the onset of clinical symptoms.
GE Healthcare offers a broad portfolio of imaging resources, which support accurate visualization of the signs of neurodegenerative diseases via state-of-the-art scanners, including MRI, PET and CT which deliver clear visualization of the brain; an expanding portfolio of imaging agents are being developed to enhance visual evidence of disease and innovative software applications which can aid physicians in image interpretation and determination of disease management. More specifically, our portfolio today includes cyclotrons and chemistry systems to manufacture PET imaging agents; PET and MR scanners to scan patients; and image analysis software to interpret the results.
GE Healthcare has also been a key contributor to the Alzheimer’s Disease Neuroimaging Initiative (ADNI) since its inception. GE Healthcare also plays a key role in PredictAD, an EU-funded research project to develop solutions to enable earlier diagnosis of AD, and Coalition Against Major Diseases (CAMD).
Additionally, the combination of our different business offerings positions us well to offer an integrated global diagnostics solution for the next generation of therapies. To that end, we are working with potential partners in the pharmaceutical industry to understand their strategic needs. and design solutions accordingly, which may support market entry via conduct of pivotal trials, provision of complex technologies, and (potentially) expedited time to market.
GE (NYSE: GE) works on things that matter. The best people and the best technologies taking on the toughest challenges. Finding solutions in energy, health and home, transportation and finance. Building, powering, moving and curing the world. Not just imagining. Doing. GE works. For more information, visit the company's website at www.ge.com.
About GE Healthcare
GE Healthcare provides transformational medical technologies and services that are shaping a new age of patient care. Our broad expertise in medical imaging and information technologies, medical diagnostics, patient monitoring systems, drug discovery, biopharmaceutical manufacturing technologies, performance improvement and performance solutions services help our customers to deliver better care to more people around the world at a lower cost. In addition, we partner with healthcare leaders, striving to leverage the global policy change necessary to implement a successful shift to sustainable healthcare systems.
For more information about GE Healthcare, visit our website at www.gehealthcare.com.
More Insight and Advice from the Alzheimer's Reading Room
- How Alzheimer's Spreads Throughout the Brain
- Test Your Memory for Alzheimer's (5 Best Self Assessment Tests)
- What is Alzheimer's Disease?
- What is Dementia?
- What’s the Difference Between Alzheimer’s Disease and Dementia
- Communicating in Alzheimer's World
- How the Loss of Memory Works in Alzheimer’s Disease, and How Understanding This Could Help You
- Learning How to Communicate with Someone Suffering From Alzheimer's Disease
- Alzheimer's World -- Trying to Reconnect with Someone Suffering from Alzheimer's Disease
- Does the Combination of Aricept and Namenda Help Slow the Rate of Decline in Alzheimer's Patients
- Driving with Alzheimer's Can Mean Death
- About the Alzheimer's Reading Room
Original content Bob DeMarco, the Alzheimer's Reading Room