Until now, physicians have been limited in their ability to diagnose Alzheimer's disease, guided almost exclusively by a patient's mental and behavioral symptoms and family history.
Alzheimer's Reading Room
Right now, the only way a diagnosis of Alzheimer's disease can be confirmed is with an autopsy.
Because the diagnosis is not currently definitive many Alzheimer's caregivers and their families are left wondering if it really is Alzheimer's, some other type of dementia, or something else. Something else? Is the cause of the memory problems or cognitive deficiencies being caused by something that is treatable?
I'll admit, in the beginning with Dotty I was always hoping that we would find some other cause of her dementia like symptoms, and that an already available treatment would cure her. Essentially wake her up, bring her back. I'm sure many caregivers have similar thoughts.
I know the importance of early detection is often misunderstood. Most assume that if their is no viable treatment, why bother? However, it is imperative to get an early diagnosis because there is a growing body of evidence indicating that early detection leads to better outcomes. A higher quality of life is one important reason.
These tests, if successful, will make a difference.
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Mount Sinai Performs First Imaging Test to Detect Alzheimer's Disease in the Clinical Setting
The new technique is expected to play a critical role in Alzheimer's disease diagnosis and in research leading to a cure.
|Samuel E. Gandy|
The innovative technique—recently approved by the U.S. Food and Drug Administration (FDA), is not only expected to play a critical role in the diagnosis of AD, but in drug research, and the design of clinical trials leading to a cure.
Under the new procedure, patients are injected with a radioactive agent called florbetapir, which binds to the plaques that are hallmark symptoms of AD. The physician then uses a positron emission tomography (PET) scan to highlight the plaques that are binded to the agent. If a large amount of florbetapir is visualized on the image, the patient may have AD. If no plaques are found, this could eliminate AD as a possible cause of the patient's cognitive impairment.
"Until now, a diagnosis of Alzheimer's disease could only be pathologically confirmed at autopsy," said Samuel Gandy, MD, Professor of Neurology and Psychiatry and Director of the Mount Sinai Center for Cognitive Health and NFL Neurological Center at The Mount Sinai Medical Center. "Coupled with traditional clinical examination, florbetapir is a promising tool in helping confirm the diagnosis of a patient who is dealing with cognitive impairment. While we cannot exclude the presence of very low levels of amyloid, a negative test means that a memory problem is likely due to some other cause."Alzheimer's disease is one of several possible causes of cognitive decline. Symptoms may overlap with other causes of cognitive impairment including memory loss; loss in visuospatial ability and executive function; and behavioral and language difficulties. The imaging technique will be used as an adjunctive tool with traditional methods of diagnosis to help determine if these symptoms are related to AD and if not, eliminate it as a likely cause of them.
"The approval of this agent by the FDA for PET imaging of the brain, already available at The Mount Sinai Medical Center, marks a significant advance in the evaluation of patients suspected of having or being at risk for Alzheimer's Disease," said Josef Machac, MD, Director of Nuclear Medicine and Professor of Radiology at The Mount Sinai Medical Center. "The principal value of this procedure at this time is in excluding beta-amyloid and Alzheimer's disease as cause for memory or cognitive decline. This can help in patient management, and in clinical trials of investigational therapies to find more effective treatment."Florbetapir is anticipated to be most useful in the research setting, providing scientists with a tool for measuring the efficacy of certain drugs on patients who present with cognitive impairment or AD. The scan will help determine which patients are appropriate for which trials, which drugs are effective and for what duration, and provide a better assessment for disease progression.
"From a research perspective, this imaging technique is a major advance that will propel us forward in designing clinical trials and determining drug efficacy for this debilitating disease," said Dr. Gandy. "I look forward to using it both in my clinical practice to help diagnose my patients, and in my research on the quest for a cure for Alzheimer's disease."
AD is an incurable, progressive neurodegenerative disease affecting more than five million people worldwide, and is the leading cause of dementia in the elderly. Presently, there is no cure for Alzheimer's disease.
Florbetapir is marketed as Amyvid™ by Eli Lilly and Company and Avid Radiopharmaceuticals, Inc., a wholly owned subsidiary of Lilly.
About The Mount Sinai Medical Center
The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Mount Sinai School of Medicine. Established in 1968, Mount Sinai School of Medicine is one of the leading medical schools in the United States. The Medical School is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service.
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Original content Bob DeMarco, the Alzheimer's Reading Room