Bexarotene, a cancer drug touted as a potential treatment for Alzheimer’s disease, may not be the blockbuster remedy that scientist were hoping for.
Bob De Marco
+Alzheimer's Reading Room
|Co-authors Karthikeyan Veeraraghavalu and|
Sangram Sisodia of the University of Chicago
The original results, presented online Feb. 9, 2012, suggested that the drug bexarotene could rapidly reverse the buildup of beta amyloid plaques (Aβ) — a pathological hallmark of Alzheimer’s disease — in the brains of mice.
According to the authors of the 2012 report, drug treatment quickly removed most of the plaques and brought rapid reversal of the pathological, cognitive and memory deficits related to the onset of Alzheimer’s.
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Interestingly, The Alzheimer's Drug Discovery Foundation (ADDF) and BrightFocus Foundation recently announced a funding collaboration that will support a Phase I human clinical trial to evaluate bexarotene as a treatment for Alzheimer's disease.
The trial will be conducted by ReXceptor Inc., a biotechnology company set-up by researchers at Case Western Reserve University (CWRU), and will examine the efficacy of bexarotene on key Alzheimer's disease indicators, including brain amyloid beta and apolipoprotein E (apoE).
Please read the following carefully. Three independent studies failed to confirm the 2012 study using Bexarotene as an effective treatment for Alzheimer's in mice.
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The new reports from three carefully controlled studies failed to replicate the results of the 2012 study; and, did not show any reduction in the number of plaques or total area occupied by the plaques during or after treatment. The new findings will be published in the May 24, 2013, issue of Science.
These results are described in three “technical comments” — one of which comes from researchers at the University of Chicago, Northwestern University, Massachusetts General Hospital, Washington University in St Louis and University of Tubingen in Germany.
- “The drug has no impact on plaque burden in three strains that exhibit Aβ amyloidosis,” according to that group's comment. “We have failed to support earlier findings by Cramer et al that Targretin is efficacious in reducing plaque burden in transgenic mouse models of cerebral Aβ deposition.”
- “We were surprised and excited, even stunned, when we first saw these results presented at a small conference,” said Sisodia. “The mechanism of action made some sense, but the assertion that they could reduce the areas of plaque by 50 percent within three days, and by 75 percent in two weeks, seemed too good to be true.”
- “We all went back to our labs and tried to confirm these promising findings,” Sisodia added. “We repeated the initial experiments — a standard process in science. Combined results are really important in this field. None of us found anything like what they described in the 2012 paper.” The researchers found no effects on plaque burden in three different strains of mice that were treated with bexarotene.
- The discrepancy, besides being disappointing, also raises concerns about patient safety. The Food and Drug Administration approved bexarotene in December 1999 for a very specific use: treatment of refractory cutaneous T-cell lymphoma, a type of skin cancer. Once approved, the drug became legally available by prescription for “off-label” uses as well.
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- “Anecdotally, we have all heard that physicians are treating their Alzheimer's patients with bexarotene, a cancer drug with severe side effects,” said co-author Robert Vassar, PhD, professor of cell and molecular biology at Northwestern University Feinberg School of Medicine. “This practice should be ended immediately, given the failure of three independent research groups to replicate the plaque-lowering effects of bexarotene.”
- Bexarotene has never been tested as a treatment for Alzheimer’s disease in humans, not even to determine the optimal dose or duration of treatment. This drug has significant side effects, including major blood-lipid abnormalities, pancreatitis, liver function test abnormalities, thyroid axis alterations, leucopenia, headaches, fatigue, weight gain, depression, nausea, vomiting, constipation and rash.
This work was supported by the Cure Alzheimer’s Fund.
Additional authors include Karthikeyan Veeraraghavalu of the University of Chicago; +Rudy Tanzi , Can Zhang and Sean Miller of Massachusetts General Hospital; Jasmin K. Hefendehl and Mathias Jucker of the University of Tübingen; Tharinda W. Rajapaksha and Robert Vassar of Northwestern University Feinberg School of Medicine; and Jason Ulrich and David M. Holtzman from the Washington University School of Medicine.
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