The researchers estimate that by reducing the relative risk from seven known risk factors associated with Alzheimer's disease, the number of people living with Alzheimer's could be reduced by 8.5%.Alzheimer's Reading Room
Alzheimer’s disease is caused by a complex interplay of genetic and lifestyle factors.Tackling physical inactivity will reduce levels of obesity, hypertension and diabetes, and prevent some people from developing dementia – it’s a win-win situation
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The estimate is lower than the previous estimate of one in two cases as it takes into account the fact some of the risk factors used in previous studies are related. For example, three of the risk factors (diabetes, hypertension and obesity) are linked with physical inactivity and all of these are related to educational level.
Current estimates suggest that by 2050, more than 106 million people will be living with Alzheimer’s disease, a huge increase on the 30 million people affected by the disease in 2010. Alzheimer’s disease is caused by a complex interplay of genetic and lifestyle factors.
Amongst the greatest lifestyle factors are lack of exercise, smoking, poor educational attainment and depression, all of which can be targeted to reduce the risk.
- A study published in 2011 suggested that as many as one in two cases of Alzheimer’s could potentially be prevented by modifying lifestyle factors.
- However, this newer study treated the risk factors as being independent of one another.
- Led by Professor Carol Brayne from the Cambridge Institute of Public Health at the University of Cambridge and involving co-authors from the 2011 study, this estimate has been lowered to one in three cases.
- midlife hypertension,
- midlife obesity,
- physical inactivity,
- and low educational attainment.
Dr Deborah Barnes from the University of California, San Francisco and the San Francisco VA Medical Center, who led the 2011 study and is a co-author on this new study, says:
It’s important that we have as accurate an estimate of the projected prevalence of Alzheimer’s as possible, as well as accurate estimates of the potential impact of lifestyle changes at a societal level. Alzheimer’s disease is placing an ever increasing burden on health services worldwide as well as on both patients and their carers. Our hope is that these estimates will help public health professionals and health policy makers design effective strategies to prevent and manage thisProfessor Brayne adds:
disease. - Carol Brayne
Although there is no single way to prevent dementia, we may be able to take steps to reduce our risk of developing dementia at older ages. We know what many of these factors are, and that they are often linked. Simply tackling physical inactivity, for example, will reduce levels of obesity, hypertension and diabetes, and prevent some people from developing dementia as well as allowing a healthier old age in general – it’s a win-win situation.http://bit.ly/1kzin79
The research was funded by the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC) for Cambridgeshire and Peterborough.
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Original content Bob DeMarco, the Alzheimer's Reading Room