related_results_labels({"version":"1.0","encoding":"UTF-8","feed":{"xmlns":"http://www.w3.org/2005/Atom","xmlns$openSearch":"http://a9.com/-/spec/opensearchrss/1.0/","xmlns$georss":"http://www.georss.org/georss","xmlns$thr":"http://purl.org/syndication/thread/1.0","id":{"$t":"tag:blogger.com,1999:blog-6471983413705881126"},"updated":{"$t":"2010-09-09T13:52:39.916-04:00"},"title":{"type":"text","$t":"Alzheimer's Reading Room"},"subtitle":{"type":"html","$t":"The Alzheimers Reading Room has clear, concise, usable news, research, insight and advice for the entire Alzheimers community. The website focuses on those suffering from Alzheimers disease and Dementia, Alzheimers caregivers, and the art of Alzheimers caregiving. 100 Million people have been touched by Alzheimer's disease, and 35 million are worried about Alzheimer's."},"link":[{"rel":"http://schemas.google.com/g/2005#feed","type":"application/atom+xml","href":"http://www.alzheimersreadingroom.com/feeds/posts/default"},{"rel":"self","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/-/research?alt\u003djson-in-script\u0026max-results\u003d5"},{"rel":"alternate","type":"text/html","href":"http://www.alzheimersreadingroom.com/search/label/research"},{"rel":"hub","href":"http://pubsubhubbub.appspot.com/"},{"rel":"next","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/-/research/-/research?alt\u003djson-in-script\u0026start-index\u003d6\u0026max-results\u003d5"}],"author":[{"name":{"$t":"Bob DeMarco"},"uri":{"$t":"http://www.blogger.com/profile/14861703129474871916"},"email":{"$t":"rtdemarco@gmail.com"}}],"generator":{"version":"7.00","uri":"http://www.blogger.com","$t":"Blogger"},"openSearch$totalResults":{"$t":"81"},"openSearch$startIndex":{"$t":"1"},"openSearch$itemsPerPage":{"$t":"5"},"entry":[{"id":{"$t":"tag:blogger.com,1999:blog-6471983413705881126.post-5596719334279365570"},"published":{"$t":"2010-09-02T08:42:00.009-04:00"},"updated":{"$t":"2010-09-02T11:34:26.593-04:00"},"category":[{"scheme":"http://www.blogger.com/atom/ns#","term":"tumors"},{"scheme":"http://www.blogger.com/atom/ns#","term":"alzheimer's"},{"scheme":"http://www.blogger.com/atom/ns#","term":"research"},{"scheme":"http://www.blogger.com/atom/ns#","term":"Gleevec"},{"scheme":"http://www.blogger.com/atom/ns#","term":"medical science"},{"scheme":"http://www.blogger.com/atom/ns#","term":"life news"},{"scheme":"http://www.blogger.com/atom/ns#","term":"leukemia"},{"scheme":"http://www.blogger.com/atom/ns#","term":"science"}],"title":{"type":"text","$t":"Gleevec -- Scientists Identify Protein that Spurs Formation of Alzheimer’s Plaques"},"content":{"type":"html","$t":"\u003ci\u003e\u003cb\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: x-small;\"\u003eAlzheimer's Reading Room \u003c/span\u003e\u003c/b\u003e\u003c/i\u003e  \u003cbr /\u003e\u003cbr /\u003e\u003cblockquote\u003e\u003cdiv class\u003d\"separator\" style\u003d\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em; text-align: center;\"\u003e\u003cimg border\u003d\"0\" height\u003d\"150\" src\u003d\"http://3.bp.blogspot.com/_UUEwElMfh90/TH-cnAGJpwI/AAAAAAAACbw/sLfsiY8yjEU/s200/Paul+Greengard.gif\" width\u003d\"150\" /\u003e\u003c/div\u003e\u003cb\u003e“Anti-amyloid therapeutic drugs represent a valid approach to treating Alzheimer’s disease, but their inability to accumulate in the brain has limited their usefulness,” says Greengard, who is head of the Laboratory of Molecular and Cellular Neuroscience. \u003cbr /\u003e\u003cbr /\u003e“The development of compounds that work like Gleevec, but have the ability to pass the blood-brain barrier and target GSAP, could revolutionize the treatment of this disease.” \u003c/b\u003e\u003c/blockquote\u003e\u003cbr /\u003eA version of the cancer drug Gleevec could form the basis of a new class of drugs that block the development of brain-damaging plaques in Alzheimer's disease. \u003cbr /\u003e\u003cbr /\u003eThe latest study shows γ-secretase activating protein (GSAP) increases the production of beta amyloid. Blocking the protein in genetically engineered mice kept Alzheimer's brain plaques from developing.\u003cbr /\u003e\u003cbr /\u003e\u003ca name\u003d'more'\u003e\u003c/a\u003e\u003cbr /\u003eIn Alzheimer’s disease, the problem is amyloid-β, a protein that accumulates in the brain and causes nerve cells to weaken and die. Drugs designed to eliminate plaques made of amyloid-β have a fatal problem: they need to enter the brain and remove the plaques without attacking healthy brain cells. \u003cbr /\u003e\u003cbr /\u003eA new breakthrough from the laboratory of Nobel Prize winner Paul Greengard, however, suggests that treatments modeled on the blockbuster cancer drug Gleevec could be the solution. The findings are reported in the September 2 issue of the journal Nature. \u003cbr /\u003e\u003cbr /\u003eGleevec, it turns out, has the unique ability to bind to a protein that triggers the production of amyloid-β plaques. \u003cbr /\u003e\u003cbr /\u003eThe new research from Greengard’s lab shows that this protein, called γ-secretase activating protein (GSAP), dramatically and selectively increases the production of amyloid-β peptide, which makes up the senile plaques found in the brains of most people with Alzheimer’s. GSAP works through a mechanism involving its interactions with γ-secretase, an enzyme that chops up the amyloid precursor protein, a large molecule produced naturally in the body and found in many different types of cells. \u003cbr /\u003e\u003cbr /\u003e\u003cb\u003e“Alzheimer’s disease is a devastating disorder for which there are no satisfactory treatments,” says Greengard, Vincent Astor Professor and director of the Fisher Center for Alzheimer’s Research at Rockefeller. “Our findings reveal that γ-secretase activating protein is a potential target for a new class of anti-amyloid therapies.” Greengard won the 2000 Nobel Prize in Physiology or Medicine for research into how neurons communicate. \u003c/b\u003e\u003cbr /\u003e\u003cbr /\u003eScientists have been searching for ways to reduce amyloid-β production in Alzheimer’s patients by blocking γ-secretase, but most γ-secretase inhibitors also block the cleavage of an important immune system molecule called Notch. \u003cbr /\u003e\u003cbr /\u003eNotch plays a pivotal role in the development of blood-forming organs and the immune system. Earlier research by Greengard and his colleagues showed that Gleevec, a drug used to treat leukemia and gastrointestinal stromal tumors, successfully inhibited the ability of γ-secretase to form amyloid-β without affecting the Notch pathway. \u003cbr /\u003e\u003cbr /\u003eIn the new study, led by Gen He, a research associate in Greengard’s lab, the researchers showed that GSAP stimulates production of amyloid-β in cell lines, and that reducing GSAP reduces amyloid-β. The researchers also looked at GSAP’s action in a mouse model of Alzheimer’s disease. They knocked down the gene that codes for GSAP using RNA interference, and found that levels of amyloid-β as well as plaque development decreased. Biochemical studies showed that Gleevec reduces amyloid-β production by binding to GSAP and preventing its activation of γ-secretase. \u003cbr /\u003e\u003cbr /\u003e\u003cb\u003eUnfortunately, the Gleevec molecule does not cross the blood-brain barrier, the gatekeeper that prevents some substances in the blood from entering the brain. Greengard, however, believes that it will be possible to design drugs that target GSAP but do not have this limitation. \u003c/b\u003e\u003cbr /\u003e\u003cbr /\u003e\u003cb\u003e“Anti-amyloid therapeutic drugs represent a valid approach to treating Alzheimer’s disease, but their inability to accumulate in the brain has limited their usefulness,” says Greengard, who is head of the Laboratory of Molecular and Cellular Neuroscience. “The development of compounds that work like Gleevec, but have the ability to pass the blood-brain barrier and target GSAP, could revolutionize the treatment of this disease.” \u003c/b\u003e\u003cbr /\u003e\u003cbr /\u003eGood coverage of this research in the New York Times -- \u003ca href\u003d\"http://www.nytimes.com/2010/09/02/health/research/02alzheimer.html?_r\u003d1\"\u003e\u003cb\u003eFinding Suggests New Aim for Alzheimer’s Drugs\u003c/b\u003e\u003c/a\u003e\u003cbr /\u003e_____________________\u003cbr /\u003e\u003cbr /\u003eNature 467: 95–98 (September 2, 2010)\u003cbr /\u003eGamma-secretase activating protein is a therapeutic target for Alzheimer’s disease \u003cbr /\u003eGen He, Wenjie Luo, Peng Li, Christine Remmers, William J. Netzer, Joseph Hendrick, Karima Bettayeb, Marc Flajolet, Fred Gorelick, Lawrence P. Wennogle and Paul Greengard\u003cbr /\u003e\u003cbr /\u003e\u003ciframe allowtransparency\u003d\"true\" frameborder\u003d\"0\" scrolling\u003d\"no\" src\u003d\"http://www.facebook.com/plugins/like.php?href\u003dhttp%3A%2F%2Fwww.alzheimersreadingroom.com\u0026amp;layout\u003dstandard\u0026amp;show_faces\u003dtrue\u0026amp;width\u003d450\u0026amp;action\u003drecommend\u0026amp;colorscheme\u003dlight\u0026amp;height\u003d80\" style\u003d\"border: none; height: 80px; overflow: hidden; width: 450px;\"\u003e\u003c/iframe\u003e  \u003cbr /\u003e\u003cbr /\u003e\u003cform action\u003d\"http://feedburner.google.com/fb/a/mailverify\" method\u003d\"post\" onsubmit\u003d\"window.open('http://feedburner.google.com/fb/a/mailverify?uri\u003dTheAlzheimersReadingRoom', 'popupwindow', 'scrollbars\u003dyes,width\u003d495,height\u003d468');return true\" style\u003d\"border: 1px solid #ccc; padding: 2 px; text-align: center;\" target\u003d\"popupwindow\"\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: large;\"\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"color: teal;\"\u003eSubscribe to the Alzheimer's Reading Room\u003c/span\u003e\u003c/span\u003e \u003cbr /\u003e\u003cb\u003eEnter Your Email Address\u003c/b\u003e  \u003cbr /\u003e\u003cinput name\u003d\"email\" style\u003d\"width: 200px;\" type\u003d\"text\" /\u003e\u003cinput name\u003d\"uri\" type\u003d\"hidden\" value\u003d\"TheAlzheimersReadingRoom\" /\u003e\u003cinput name\u003d\"loc\" type\u003d\"hidden\" value\u003d\"en_US\" /\u003e\u003cinput type\u003d\"submit\" value\u003d\"Subscribe\" /\u003e\u003c/form\u003e\u003cbr /\u003e\u003ccenter\u003e\u003cb\u003eMore About the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/b\u003e\u003c/center\u003e\u003cb\u003e\u003cbr /\u003e\u003cul\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/alzheimers-reading-room-testimonials.html\"\u003e60 Good Reasons to Subscribe to the Alzheimer's Reading Room \u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/advice-and-insight-alzheimers.html\"\u003eAlzheimer's CareGiving -- Insight and Advice\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/topic-test-your-memory-for-alzheimers.html\"\u003eTest Your Memory for Alzheimer's (5 Best Self Assessment Tests)\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/12/communicating-in-alzheimers-world.html\"\u003eCommunicating in  Alzheimer's World\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/11/worried-about-alzheimers-disease.html\"\u003eWorried About Alzheimer's Disease -- You Should Be\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/what-is-alzheimers-what-are-eight-types.html\"\u003eWhat is Alzheimer's? What are the Eight Types of Dementia?\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/does-combination-of-aricept-and-namenda.html\"\u003eDoes the Combination of Aricept and Namenda Help Slow the Rate of Decline in Alzheimer's Patients\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/alzheimers-statistics.html\"\u003eAlzheimer's Disease Statistics\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003cb\u003e\u003cb\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/03/is-it-really-alzheimers-or-something.html\"\u003eIs it Really Alzheimer's or Something Else?\u003c/a\u003e\u003c/b\u003e\u003c/b\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/05/ten-symptoms-of-early-stage-alzheimers.html\"\u003eTen Symptoms of Early Stage Alzheimer's\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/ten-tips-for-communicating-with.html\"\u003eTen Tips for Communicating with an Alzheimer’s Patient\u003c/a\u003e\u003c/li\u003e\u003c/ul\u003e\u003c/b\u003e  \u003cbr /\u003e\u003cbr /\u003e\u003cblockquote\u003e\u003cdiv class\u003d\"separator\" style\u003d\"clear: both; text-align: left;\"\u003e\u003cimg border\u003d\"0\" height\u003d\"85\" src\u003d\"http://2.bp.blogspot.com/_UUEwElMfh90/SPDjt6cT4-I/AAAAAAAABMQ/MXL3uRljPQU/s200/Head+shot+5.JPG\" style\u003d\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\" width\u003d\"85\" /\u003e\u003c/div\u003e\u003cspan style\u003d\"font-size: small;\"\u003e\u003cb\u003e\u003cb\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/09/bob-demarco-editorcontributor.html\"\u003eBob DeMarco\u003c/a\u003e\u003c/b\u003e\u003c/b\u003e\u003c/span\u003e\u003cb\u003e is the editor of the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e and an Alzheimer's caregiver. Bob has written more than 1,810 articles with more than 89,500 links on the Internet. Bob resides in Delray Beach, FL.\u003c/b\u003e  \u003c/blockquote\u003e\u003cbr /\u003e\u003ccenter\u003e\u003ctable\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align\u003d\"center\"\u003e\u003cimg src\u003d\"http://ws.amazon.com/widgets/q?MarketPlace\u003dUS\u0026amp;ServiceVersion\u003d20070822\u0026amp;ID\u003dAsinImage\u0026amp;WS\u003d1\u0026amp;Format\u003d_SL150_\u0026amp;ASIN\u003dB002KHMZQ8\u0026amp;tag\u003dalzside-20\" /\u003e\u003cbr /\u003e\u003ca href\u003d\"http://www.amazon.com/Alzheimers-Action-Plan-Diagnosis-Treatment/dp/B002KHMZQ8?ie\u003dUTF8\u0026amp;tag\u003dalzside-20\"\u003e\u003cb\u003eThe Alzheimer's Action Plan\u003c/b\u003e\u003c/a\u003e \u003c/td\u003e\u003ctd width\u003d\"32\"\u003e\u0026nbsp; \u003c/td\u003e\u003ctd align\u003d\"center\"\u003e\u003cimg src\u003d\"http://ws.amazon.com/widgets/q?MarketPlace\u003dUS\u0026amp;ServiceVersion\u003d20070822\u0026amp;ID\u003dAsinImage\u0026amp;WS\u003d1\u0026amp;Format\u003d_SL150_\u0026amp;ASIN\u003d1932603166\u0026amp;tag\u003dalzside-20\" /\u003e\u003cbr /\u003e\u003ca href\u003d\"http://www.amazon.com/Caregivers-Guide-Alzheimers-Disease-Making/dp/1932603166?ie\u003dUTF8\u0026amp;tag\u003dalzside-20\"\u003e\u003cb\u003e300 Tips for Making Life Easier\u003c/b\u003e\u003c/a\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/table\u003e\u003ccenter\u003e\u003c/center\u003e\u003c/center\u003e  \u003cbr /\u003e\u003cbr /\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: large;\"\u003eOriginal content Bob DeMarco, the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/09/scientists-identify-protein-that-spurs.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/span\u003e\u003cdiv class\u003d\"blogger-post-footer\"\u003e\u003cimg width\u003d'1' height\u003d'1' src\u003d'https://blogger.googleusercontent.com/tracker/6471983413705881126-5596719334279365570?l\u003dwww.alzheimersreadingroom.com' alt\u003d'' /\u003e\u003c/div\u003e"},"link":[{"rel":"replies","type":"application/atom+xml","href":"http://www.alzheimersreadingroom.com/feeds/5596719334279365570/comments/default","title":"Post Comments"},{"rel":"replies","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/09/scientists-identify-protein-that-spurs.html#comment-form","title":"0 Comments"},{"rel":"edit","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/5596719334279365570"},{"rel":"self","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/5596719334279365570"},{"rel":"alternate","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/09/scientists-identify-protein-that-spurs.html","title":"Gleevec -- Scientists Identify Protein that Spurs Formation of Alzheimer’s Plaques"}],"author":[{"name":{"$t":"Bob DeMarco"},"uri":{"$t":"http://www.blogger.com/profile/14861703129474871916"},"email":{"$t":"rtdemarco@gmail.com"},"gd$extendedProperty":{"xmlns$gd":"http://schemas.google.com/g/2005","name":"OpenSocialUserId","value":"02937219926706406775"}}],"media$thumbnail":{"xmlns$media":"http://search.yahoo.com/mrss/","url":"http://3.bp.blogspot.com/_UUEwElMfh90/TH-cnAGJpwI/AAAAAAAACbw/sLfsiY8yjEU/s72-c/Paul+Greengard.gif","height":"72","width":"72"},"thr$total":{"$t":"0"}},{"id":{"$t":"tag:blogger.com,1999:blog-6471983413705881126.post-6559322447785785717"},"published":{"$t":"2010-08-16T08:39:00.001-04:00"},"updated":{"$t":"2010-08-16T08:57:24.487-04:00"},"category":[{"scheme":"http://www.blogger.com/atom/ns#","term":"tension"},{"scheme":"http://www.blogger.com/atom/ns#","term":"symptoms"},{"scheme":"http://www.blogger.com/atom/ns#","term":"health"},{"scheme":"http://www.blogger.com/atom/ns#","term":"sleeping"},{"scheme":"http://www.blogger.com/atom/ns#","term":"anxiety"},{"scheme":"http://www.blogger.com/atom/ns#","term":"irritation"},{"scheme":"http://www.blogger.com/atom/ns#","term":"women"},{"scheme":"http://www.blogger.com/atom/ns#","term":"research"},{"scheme":"http://www.blogger.com/atom/ns#","term":"lifestyle"},{"scheme":"http://www.blogger.com/atom/ns#","term":"Alzheimer's disease"},{"scheme":"http://www.blogger.com/atom/ns#","term":"dementia"},{"scheme":"http://www.blogger.com/atom/ns#","term":"life news"},{"scheme":"http://www.blogger.com/atom/ns#","term":"stress"},{"scheme":"http://www.blogger.com/atom/ns#","term":"brain"}],"title":{"type":"text","$t":"Stress in middle age could contribute to late life dementia"},"content":{"type":"html","$t":"\u003ci\u003e\u003cb\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: small;\"\u003eBy Bob DeMarco\u003c/span\u003e\u003c/b\u003e\u003c/i\u003e    \u003cbr /\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: small;\"\u003eAlzheimer's Reading Room\u003c/span\u003e  \u003cbr /\u003e\u003cbr /\u003ePsychological stress in middle age could lead to the development of dementia later in life. Based on data from a study which followed women for 35 years, this is the first research in Sweden to indicate a link between stress and dementia. \u003cbr /\u003e\u003cbr /\u003e\u003ca name\u003d'more'\u003e\u003c/a\u003e \u003cbr /\u003eThe research, published in prestigious scientific journal Brain, is based on a major population study of women from Gothenburg. A representative sample of women were examined for the first time in 1968 when aged between 38 and 60, and then re-examined in 1974, 1980, 1992 and 2000.\u003cbr /\u003e\u003cbr /\u003eA question about psychological stress was included in the 1968, 1974 and 1980 surveys and was answered by 1,415 women.\u003cbr /\u003e\u003cblockquote\u003e“Stress was defined as a sense of irritation, tension, nervousness, anxiety, fear or sleeping problems lasting a month or more due to work, health, family or other problems,” explains Lena Johansson, a researcher from the Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy’s Department of Psychiatry and Neurochemistry.\u003c/blockquote\u003e\u003cbr /\u003eDuring the 35 years of the study, 161 of the participants developed dementia, mainly in the form of Alzheimer’s disease. The risk of dementia was about 65% higher in women who reported repeated periods of stress in middle age than in those who did not. In women who reported stress in all three surveys, the risk more than doubled.\u003cbr /\u003e\u003cbr /\u003e“This is the first study to show that stress in middle age can lead to dementia in old age, and confirms similar findings from studies of animals. Stress has previously been shown to increase the risk of cardiovascular diseases such as stroke, heart attack and hypertension,” says Johansson, who also refers to earlier research at the Sahlgrenska Academy showing that cardiovascular disease can lead to Alzheimer’s.\u003cbr /\u003e\u003cblockquote\u003e“This study could result in a better understanding of the risk factors for dementia, but our results need to be confirmed by other studies, and further research is needed in the area. Most of those who said that they were stressed did not develop dementia, so it’s not currently possible to advise people to be less stressed or warn about the dangers of high stress levels due to an increased risk of developing dementia.”\u003c/blockquote\u003e\u003cbr /\u003eDEMENTIA\u003cbr /\u003e\u003cbr /\u003eDementia is a deterioration of the intellect, memory and personality. It results from disorders and damage that affect the brain, including Alzheimer’s disease. Symptoms include forgetfulness, impaired speech and emotional blunting. Dementia is common in Sweden, increasingly so as we get older. It is estimated that around 7% of the Swedish population over the age of 65 and just over 20% of the over-80s have severe dementia.\u003cbr /\u003e\u003cbr /\u003e\u003ciframe src\u003d\"http://www.facebook.com/plugins/like.php?href\u003dhttp%3A%2F%2Fwww.alzheimersreadingroom.com\u0026amp;layout\u003dstandard\u0026amp;show_faces\u003dtrue\u0026amp;width\u003d450\u0026amp;action\u003drecommend\u0026amp;colorscheme\u003dlight\u0026amp;height\u003d80\" scrolling\u003d\"no\" frameborder\u003d\"0\" style\u003d\"border:none; overflow:hidden; width:450px; height:80px;\" allowTransparency\u003d\"true\"\u003e\u003c/iframe\u003e \u003cbr /\u003e \u003cform action\u003d\"http://feedburner.google.com/fb/a/mailverify\" method\u003d\"post\" onsubmit\u003d\"window.open('http://feedburner.google.com/fb/a/mailverify?uri\u003dTheAlzheimersReadingRoom', 'popupwindow', 'scrollbars\u003dyes,width\u003d495,height\u003d468');return true\" style\u003d\"border: 1px solid #ccc; padding: 2 px; text-align: center;\" target\u003d\"popupwindow\"\u003e\u003cspan class\u003d\"Apple-style-span\"  style\u003d\"font-size:large;\"\u003e\u003cspan class\u003d\"Apple-style-span\"  style\u003d\"color:#008080;\"\u003eSubscribe to the Alzheimer's Reading Room\u003c/span\u003e\u003c/span\u003e \u003cp\u003e\u003cb\u003eEnter Your Email Address\u003c/b\u003e  \u003cp\u003e\u003cinput name\u003d\"email\" style\u003d\"width: 200px;\" type\u003d\"text\" /\u003e\u003cinput name\u003d\"uri\" type\u003d\"hidden\" value\u003d\"TheAlzheimersReadingRoom\" /\u003e\u003cinput name\u003d\"loc\" type\u003d\"hidden\" value\u003d\"en_US\" /\u003e\u003cinput type\u003d\"submit\" value\u003d\"Subscribe\" /\u003e\u003c/p\u003e\u003c/form\u003e\u003cbr /\u003e\u003ccenter\u003e\u003cb\u003eMore About the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/b\u003e\u003c/center\u003e\u003cb\u003e\u003cul\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/alzheimers-reading-room-testimonials.html\"\u003e60 Good Reasons to Subscribe to the Alzheimer's Reading Room \u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/advice-and-insight-alzheimers.html\"\u003eAlzheimer's CareGiving -- Insight and Advice\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/topic-test-your-memory-for-alzheimers.html\"\u003eTest Your Memory for Alzheimer's (5 Best Self Assessment Tests)\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/12/communicating-in-alzheimers-world.html\"\u003eCommunicating in  Alzheimer's World\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/11/worried-about-alzheimers-disease.html\"\u003eWorried About Alzheimer's Disease -- You Should Be\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/what-is-alzheimers-what-are-eight-types.html\"\u003eWhat is Alzheimer's? What are the Eight Types of Dementia?\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/does-combination-of-aricept-and-namenda.html\"\u003eDoes the Combination of Aricept and Namenda Help Slow the Rate of Decline in Alzheimer's Patients\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/alzheimers-statistics.html\"\u003eAlzheimer's Disease Statistics\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003cb\u003e\u003cb\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/03/is-it-really-alzheimers-or-something.html\"\u003eIs it Really Alzheimer's or Something Else?\u003c/a\u003e\u003c/b\u003e\u003c/b\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/05/ten-symptoms-of-early-stage-alzheimers.html\"\u003eTen Symptoms of Early Stage Alzheimer's\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/ten-tips-for-communicating-with.html\"\u003eTen Tips for Communicating with an Alzheimer’s Patient\u003c/a\u003e\u003c/li\u003e\u003c/ul\u003e\u003c/b\u003e  \u003cbr /\u003e\u003cblockquote\u003e\u003cdiv class\u003d\"separator\" style\u003d\"clear: both; text-align: left;\"\u003e\u003cimg border\u003d\"0\" height\u003d\"85\" src\u003d\"http://2.bp.blogspot.com/_UUEwElMfh90/SPDjt6cT4-I/AAAAAAAABMQ/MXL3uRljPQU/s200/Head+shot+5.JPG\"  style\u003d\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\" width\u003d\"85\" /\u003e\u003c/div\u003e\u003cspan style\u003d\"font-size: small;\"\u003e\u003cb\u003e\u003cb\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/09/bob-demarco-editorcontributor.html\"\u003eBob DeMarco\u003c/a\u003e\u003c/b\u003e\u003c/b\u003e\u003c/span\u003e\u003cb\u003e is the editor of the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e and an Alzheimer's caregiver. Bob has written more than 1,690 articles with more than 70,000 links on the Internet. Bob resides in Delray Beach, FL.\u003c/b\u003e  \u003c/blockquote\u003e\u003cbr /\u003e\u003ccenter\u003e\u003ciframe src\u003d\"http://rcm.amazon.com/e/cm?t\u003darrarticle-20\u0026o\u003d1\u0026p\u003d12\u0026l\u003dur1\u0026category\u003dkindle\u0026banner\u003d1RR50DN6TK7D02JARP02\u0026f\u003difr\" width\u003d\"300\" height\u003d\"250\" scrolling\u003d\"no\" border\u003d\"0\" marginwidth\u003d\"0\" style\u003d\"border:none;\" frameborder\u003d\"0\"\u003e\u003c/iframe\u003e\u003c/center\u003e \u003cbr /\u003e\u003cbr /\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: large;\"\u003eOriginal content Bob DeMarco, the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/08/stress-in-middle-age-could-contribute.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/span\u003e\u003cdiv class\u003d\"blogger-post-footer\"\u003e\u003cimg width\u003d'1' height\u003d'1' src\u003d'https://blogger.googleusercontent.com/tracker/6471983413705881126-6559322447785785717?l\u003dwww.alzheimersreadingroom.com' alt\u003d'' /\u003e\u003c/div\u003e"},"link":[{"rel":"replies","type":"application/atom+xml","href":"http://www.alzheimersreadingroom.com/feeds/6559322447785785717/comments/default","title":"Post Comments"},{"rel":"replies","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/08/stress-in-middle-age-could-contribute.html#comment-form","title":"0 Comments"},{"rel":"edit","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/6559322447785785717"},{"rel":"self","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/6559322447785785717"},{"rel":"alternate","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/08/stress-in-middle-age-could-contribute.html","title":"Stress in middle age could contribute to late life dementia"}],"author":[{"name":{"$t":"Bob DeMarco"},"uri":{"$t":"http://www.blogger.com/profile/14861703129474871916"},"email":{"$t":"rtdemarco@gmail.com"},"gd$extendedProperty":{"xmlns$gd":"http://schemas.google.com/g/2005","name":"OpenSocialUserId","value":"02937219926706406775"}}],"media$thumbnail":{"xmlns$media":"http://search.yahoo.com/mrss/","url":"http://2.bp.blogspot.com/_UUEwElMfh90/SPDjt6cT4-I/AAAAAAAABMQ/MXL3uRljPQU/s72-c/Head+shot+5.JPG","height":"72","width":"72"},"thr$total":{"$t":"0"}},{"id":{"$t":"tag:blogger.com,1999:blog-6471983413705881126.post-484928092776003699"},"published":{"$t":"2010-08-12T00:57:00.003-04:00"},"updated":{"$t":"2010-08-12T08:38:38.770-04:00"},"category":[{"scheme":"http://www.blogger.com/atom/ns#","term":"research"},{"scheme":"http://www.blogger.com/atom/ns#","term":"lifestyle"},{"scheme":"http://www.blogger.com/atom/ns#","term":"alzheimer's early detection"},{"scheme":"http://www.blogger.com/atom/ns#","term":"life news"},{"scheme":"http://www.blogger.com/atom/ns#","term":"health"},{"scheme":"http://www.blogger.com/atom/ns#","term":"Alzheimers Disease"},{"scheme":"http://www.blogger.com/atom/ns#","term":"studies"}],"title":{"type":"text","$t":"One Man's Case for the Early Detection of Alzheimer's Disease"},"content":{"type":"html","$t":"\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: small;\"\u003eAlzheimer's Reading Room\u003c/span\u003e \u003cbr /\u003e\u003cbr /\u003e\u003cb\u003eEditor Note:\u003c/b\u003e From time to time over the last year I have corresponded with Jay Smith via email. He is a part of the Collective Brain of the Alzheimer's Reading Room (ARR). \u003cbr /\u003e\u003cbr /\u003eFrom time to time, Jay enters comments under articles on ARR.  His comments are always on target, thought provoking, and meaningful.\u003cbr /\u003e\u003cbr /\u003eIf I was ever confused about the importance of early detection of Alzheimer's disease these doubts have been erased thanks in part to the perspective of Jay Smith and a few others.\u003cbr /\u003e\u003cbr /\u003e\u003ca name\u003d'more'\u003e\u003c/a\u003e\u003cbr /\u003eJay has taught me in no uncertain way that there is life after the diagnosis of Alzheimer's disease. He taught me to believe that early detection can in fact be a \"life sentence\" not as most believe a \"death sentence\".\u003cbr /\u003e\u003cbr /\u003eThere is one thing that makes Jay very different than the many that are now writing negatively about early detection on the Internet -- Wantland J Smith has Alzheimer's disease.\u003cbr /\u003e\u003cbr /\u003eThe following are Jay's words from a comment he sent in to ARR.\u003cbr /\u003e\u003cbr /\u003e\u003ci\u003e\u003cb\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: small;\"\u003eBy Wantland J Smith\u003c/span\u003e\u003c/b\u003e\u003c/i\u003e \u003cbr /\u003e\u003cbr /\u003eBob, \u003cbr /\u003e\u003cbr /\u003eThere is a strong move by the Alzheimer's research establishment toward early detection, diagnosis, and treatment - evidenced by the effort to develop new diagnostic criteria for three very early stages of Alzheimer's announced late last month at ICAD.  \u003cbr /\u003e\u003cbr /\u003eBut, many still share the opinion of \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/08/how-many-doctors-are-ignorant-about.html\"\u003eDr. Porras-Polo.\u003c/a\u003e \u003cbr /\u003e\u003cbr /\u003eI'm hoping they'll get the message that the distinguished leaders in the field are proclaiming about early detection and intervention being crucial to prevention and eventual cure of the disease. \u003cbr /\u003e\u003cbr /\u003eFor now, we already have a growing body of evidence, based on reputable scientific studies, that taking the combination of available Alzheimer's medications slows the progression and provides permanent benefit.  \u003cbr /\u003e\u003cbr /\u003eThere are also well documented and accepted studies that show the benefits of regular exercise, healthy nutrition, stress reduction, social activity, and brain exercises in either reducing the risk of Alzheimer's or in slowing its progression.  \u003cbr /\u003e\u003cbr /\u003e\u003cb\u003eIt is simply no longer true that \"you're not going to be able to do anything\" for it when you get your diagnosis.\u003c/b\u003e  \u003cbr /\u003e\u003cbr /\u003eA recent Los Angeles Times article (\u003ca href\u003d\"http://www.latimes.com/news/health/la-he-alzheimers-prevention-20100726,0,569270.story\"\u003eLA Times Health, July 26, 2010\u003c/a\u003e) pointed out several well accepted studies about the lifestyle changes one can do.  \u003cbr /\u003e\u003cbr /\u003eArticles from Alzheimer's Research Forum (\u003ca href\u003d\"http://www.alzforum.org/new/detail.asp?id\u003d2440\"\u003e7 May 2010\u003c/a\u003e) and Scientific American (May 6, 2010) have also helped to debunk the report of the recent NIH panel of experts negative report on lifestyle preventive measures.  \u003cbr /\u003e\u003cbr /\u003eYou have cited the studies showing the benefits of \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/does-combination-of-aricept-and-namenda.html\"\u003etaking the combination Aricept and Namenda\u003c/a\u003e, and have an active link to it on your page.  \u003cbr /\u003e\u003cbr /\u003eThe million dollar prize garnered for \u003ca href\u003d\"http://www.alz.org/alzheimers_disease_members_project.asp\"\u003e\"Early Detection Matters\" \u003c/a\u003ethe winner of the recent American Express Members' Project (created by another Jay Smith, and his wife Patty from the Washington DC area) has provided a grant, managed by Alzheimer's Association, to publicize the case for early detection and intervention. \u003cbr /\u003e\u003cbr /\u003eMy personal experience makes me sensitive to the needs of people living with preclinical and MCI symptoms of AD who may be seeking a diagnosis.  If they want to find out what's causing their symptoms, they should be able to.  The diagnosis can be liberating, as mine was, because it allows people to plan their futures and make the lifestyle adjustments necessary to enjoy the years ahead.    \u003cbr /\u003e\u003cbr /\u003eIn the meantime, let's keep putting the word out.  \u003cbr /\u003e\u003cbr /\u003eJay Smith, Los Angeles CA\u003cbr /\u003e\u003cbr /\u003e\u003cdiv class\u003d\"separator\" style\u003d\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em; text-align: center;\"\u003e\u003cimg border\u003d\"0\" height\u003d\"131\" src\u003d\"http://2.bp.blogspot.com/_UUEwElMfh90/TGN-vnqto4I/AAAAAAAACW0/IJsXu9ZFshU/s200/Jay+Smith+2.PNG\" width\u003d\"200\" /\u003e\u003c/div\u003e\u003cb\u003eWantland J. (Jay) Smith was diagnosed with early Alzheimer’s disease in late 2005, based on neuropsychological tests and FDG/PET.  \u003cbr /\u003e\u003cbr /\u003eSince diagnosis, he became an early stage Alzheimer’s advocate, creating the first early stage memory loss forum of the California Southland Chapter of the Alzheimer’s Association in October 2007, and led their second early memory loss forum in March 2009.  \u003cbr /\u003e\u003cbr /\u003eHe has participated in three early stage support groups, including the one he instigated and currently co-facilitates Leeza’s Place.  \u003cbr /\u003e\u003cbr /\u003eWith the Alzheimer’s Association he has attended two Public Policy Forums in Washington DC, recently served as a member of the Association’s second Early Stage Advisory Group, and was appointed as the first person with AD to serve on the board of directors of the California Southland Chapter, completing his two-year term in the summer of 2010.  \u003cbr /\u003e\u003cbr /\u003eHe frequently shares his story as a panelist and through press interviews.\u003c/b\u003e\u003cbr /\u003e\u003cbr /\u003e\u003cbr /\u003e\u003ciframe allowtransparency\u003d\"true\" frameborder\u003d\"0\" scrolling\u003d\"no\" src\u003d\"http://www.facebook.com/plugins/like.php?href\u003dhttp%3A%2F%2Fwww.alzheimersreadingroom.com\u0026amp;layout\u003dstandard\u0026amp;show_faces\u003dtrue\u0026amp;width\u003d450\u0026amp;action\u003drecommend\u0026amp;colorscheme\u003dlight\u0026amp;height\u003d80\" style\u003d\"border: none; height: 80px; overflow: hidden; width: 450px;\"\u003e\u003c/iframe\u003e \u003cbr /\u003e\u003cform action\u003d\"http://feedburner.google.com/fb/a/mailverify\" method\u003d\"post\" onsubmit\u003d\"window.open('http://feedburner.google.com/fb/a/mailverify?uri\u003dTheAlzheimersReadingRoom', 'popupwindow', 'scrollbars\u003dyes,width\u003d495,height\u003d468');return true\" style\u003d\"border: 1px solid #ccc; padding: 2 px; text-align: center;\" target\u003d\"popupwindow\"\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: large;\"\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"color: teal;\"\u003eSubscribe to the Alzheimer's Reading Room\u003c/span\u003e\u003c/span\u003e \u003cbr /\u003e\u003cb\u003eEnter Your Email Address\u003c/b\u003e  \u003cbr /\u003e\u003cinput name\u003d\"email\" style\u003d\"width: 200px;\" type\u003d\"text\" /\u003e\u003cinput name\u003d\"uri\" type\u003d\"hidden\" value\u003d\"TheAlzheimersReadingRoom\" /\u003e\u003cinput name\u003d\"loc\" type\u003d\"hidden\" value\u003d\"en_US\" /\u003e\u003cinput type\u003d\"submit\" value\u003d\"Subscribe\" /\u003e\u003c/form\u003e\u003cbr /\u003e\u003ccenter\u003e\u003cb\u003eMore About the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/b\u003e\u003c/center\u003e\u003cb\u003e\u003cbr /\u003e\u003cul\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/alzheimers-reading-room-testimonials.html\"\u003e60 Good Reasons to Subscribe to the Alzheimer's Reading Room \u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/advice-and-insight-alzheimers.html\"\u003eAlzheimer's CareGiving -- Insight and Advice\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/topic-test-your-memory-for-alzheimers.html\"\u003eTest Your Memory for Alzheimer's (5 Best Self Assessment Tests)\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/12/communicating-in-alzheimers-world.html\"\u003eCommunicating in  Alzheimer's World\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/11/worried-about-alzheimers-disease.html\"\u003eWorried About Alzheimer's Disease -- You Should Be\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/what-is-alzheimers-what-are-eight-types.html\"\u003eWhat is Alzheimer's? What are the Eight Types of Dementia?\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/does-combination-of-aricept-and-namenda.html\"\u003eDoes the Combination of Aricept and Namenda Help Slow the Rate of Decline in Alzheimer's Patients\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/alzheimers-statistics.html\"\u003eAlzheimer's Disease Statistics\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003cb\u003e\u003cb\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/03/is-it-really-alzheimers-or-something.html\"\u003eIs it Really Alzheimer's or Something Else?\u003c/a\u003e\u003c/b\u003e\u003c/b\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/05/ten-symptoms-of-early-stage-alzheimers.html\"\u003eTen Symptoms of Early Stage Alzheimer's\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/ten-tips-for-communicating-with.html\"\u003eTen Tips for Communicating with an Alzheimer’s Patient\u003c/a\u003e\u003c/li\u003e\u003c/ul\u003e\u003c/b\u003e  \u003cbr /\u003e\u003cbr /\u003e\u003cbr /\u003e\u003ccenter\u003e\u003ciframe border\u003d\"0\" frameborder\u003d\"0\" height\u003d\"250\" marginwidth\u003d\"0\" scrolling\u003d\"no\" src\u003d\"http://rcm.amazon.com/e/cm?t\u003darrarticle-20\u0026amp;o\u003d1\u0026amp;p\u003d12\u0026amp;l\u003dur1\u0026amp;category\u003dkindle\u0026amp;banner\u003d1RR50DN6TK7D02JARP02\u0026amp;f\u003difr\" style\u003d\"border: none;\" width\u003d\"300\"\u003e\u003c/iframe\u003e\u003c/center\u003e\u003cbr /\u003e\u003cbr /\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: large;\"\u003eOriginal content  the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/08/one-mans-case-for-early-detection-of.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/span\u003e\u003cdiv class\u003d\"blogger-post-footer\"\u003e\u003cimg width\u003d'1' height\u003d'1' src\u003d'https://blogger.googleusercontent.com/tracker/6471983413705881126-484928092776003699?l\u003dwww.alzheimersreadingroom.com' alt\u003d'' /\u003e\u003c/div\u003e"},"link":[{"rel":"replies","type":"application/atom+xml","href":"http://www.alzheimersreadingroom.com/feeds/484928092776003699/comments/default","title":"Post Comments"},{"rel":"replies","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/08/one-mans-case-for-early-detection-of.html#comment-form","title":"0 Comments"},{"rel":"edit","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/484928092776003699"},{"rel":"self","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/484928092776003699"},{"rel":"alternate","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/08/one-mans-case-for-early-detection-of.html","title":"One Man's Case for the Early Detection of Alzheimer's Disease"}],"author":[{"name":{"$t":"Bob DeMarco"},"uri":{"$t":"http://www.blogger.com/profile/14861703129474871916"},"email":{"$t":"rtdemarco@gmail.com"},"gd$extendedProperty":{"xmlns$gd":"http://schemas.google.com/g/2005","name":"OpenSocialUserId","value":"02937219926706406775"}}],"media$thumbnail":{"xmlns$media":"http://search.yahoo.com/mrss/","url":"http://2.bp.blogspot.com/_UUEwElMfh90/TGN-vnqto4I/AAAAAAAACW0/IJsXu9ZFshU/s72-c/Jay+Smith+2.PNG","height":"72","width":"72"},"thr$total":{"$t":"0"}},{"id":{"$t":"tag:blogger.com,1999:blog-6471983413705881126.post-871743922858124897"},"published":{"$t":"2010-08-01T08:38:00.001-04:00"},"updated":{"$t":"2010-08-22T19:27:31.416-04:00"},"category":[{"scheme":"http://www.blogger.com/atom/ns#","term":"research"},{"scheme":"http://www.blogger.com/atom/ns#","term":"Alzheimer's disease"},{"scheme":"http://www.blogger.com/atom/ns#","term":"life news"},{"scheme":"http://www.blogger.com/atom/ns#","term":"health"},{"scheme":"http://www.blogger.com/atom/ns#","term":"ADAM10"}],"title":{"type":"text","$t":"Researchers Identify Key Target Molecule for Alzheimer's Disease (ADAM10)"},"content":{"type":"html","$t":"\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: small;\"\u003eAlzheimer's Reading Room\u003c/span\u003e   \u003cbr /\u003e\u003cbr /\u003e\"It is possible that less ADAM10 activity could increase susceptibility to Alzheimer's disease. If that is the case, stimulating ADAM10 could be an important mechanism for therapy. But our antibodies also open up new possibilities for diagnosing and preventing the disease,\" -- Dr. Stefan Lichtenthaler.\u003cbr /\u003e\u003cbr /\u003e\u003ca name\u003d'more'\u003e\u003c/a\u003e\u003cbr /\u003eThe brains of Alzheimer patients have high accumulations of the material beta-amyloid, which appear in the form of plaques. The precursors of these plaques are believed to be the underlying cause of the nerve cell loss that leads to the disruptions in memory that characterize Alzheimer's disease.\u003cbr /\u003e\u003cbr /\u003eThe main aim of many Alzheimer therapies is therefore to inhibit the formation of beta-amyloid. Since beta-amyloid is cleaved from the so-called amyloid precursor protein (APP), scientists have focused on stopping the two enzymes that attack the precursor protein. These act like molecular scissors and cut out the beta-amyloid fragment. Blocking these scissors precludes the formation of beta-amyloid.\u003cbr /\u003e\u003cbr /\u003eDZNE and LMU researchers have succeeded in identifying an enzyme known as alpha secretase, which cleaves the amyloid precursor protein (APP) without forming beta-amyloid. Up to this point three different candidates for this function had been under consideration, but the research team has now been able to show that the enzyme ADAM10 alone is responsible for the specific cleavage. \u003cbr /\u003e\u003cbr /\u003eDr. Stefan Lichtenthaler and his team developed highly specific antibodies that can identify the different cleavage products of the precursor protein in the brain cells of mice and in human cell cultures. Using a special technique called RNA interference, \u003cb\u003ethe researchers managed to block each of the three genes that code for the three ADAM enzymes under suspicion.\u003c/b\u003e An analysis of the cleavage products revealed that the ADAM10 gene was the only one able to prevent the formation of beta-amyloids. They confirmed their results using mass spectrometry.\u003cbr /\u003e\u003cbr /\u003e\"In ADAM10 we have identified a target molecule that plays a central role in the development of the molecular processes in Alzheimer's disease. We know that ADAM10 is less active in Alzheimer patients,\" says Dr. Lichtenthaler. When ADAM10 is less active, the precursor protein is more likely to be cleaved in a way that promotes the formation of beta-amyloids.\u003cbr /\u003e\u003cbr /\u003e\"It is possible that less ADAM10 activity could increase susceptibility to Alzheimer's disease. If that is the case, stimulating ADAM10 could be an important mechanism for therapy. But our antibodies also open up new possibilities for diagnosing and preventing the disease,\" says Lichtenthaler. The antibodies could be used to measure ADAM10 activity in spinal fluid and, by extension, identify persons who may have an increased risk of developing Alzheimer's disease. A series of experiments to examine this possibility is already underway.\u003cbr /\u003e_______________________________________\u003cbr /\u003ePublication:\u003cbr /\u003e\u003cbr /\u003eADAM10 is the Physiologically Relevant, Constitutive Alpha-Secretase of the Amyloid Precursor Protein in Primary Neurons. \u003cbr /\u003ePeer-Hendrik Kuhn, Huanhuan Wang, Bastian Dislich, Alessio Colombo, Ulrike Zeitschel, Joachim W. Ellwart, Elisabeth Kremmer, Steffen Roßner, and Stefan F. Lichtenthaler, EMBO Journal, published online, 30 July 2010 doi:10.1038/emboj.2010.167\u003cbr /\u003e\u003cbr /\u003e\u003cbr /\u003e\u003ciframe src\u003d\"http://www.facebook.com/plugins/like.php?href\u003dhttp%3A%2F%2Falzheimersreadingroom.com\u0026amp;layout\u003dstandard\u0026amp;show_faces\u003dtrue\u0026amp;width\u003d450\u0026amp;action\u003drecommend\u0026amp;font\u003dverdana\u0026amp;colorscheme\u003dlight\u0026amp;height\u003d80\" scrolling\u003d\"no\" frameborder\u003d\"0\" style\u003d\"border:none; overflow:hidden; width:450px; height:80px;\" allowTransparency\u003d\"true\"\u003e\u003c/iframe\u003e  \u003cform action\u003d\"http://feedburner.google.com/fb/a/mailverify\" method\u003d\"post\" onsubmit\u003d\"window.open('http://feedburner.google.com/fb/a/mailverify?uri\u003dTheAlzheimersReadingRoom', 'popupwindow', 'scrollbars\u003dyes,width\u003d495,height\u003d468');return true\" style\u003d\"border: 1px solid #ccc; padding: 2 px; text-align: center;\" target\u003d\"popupwindow\"\u003e\u003cspan class\u003d\"Apple-style-span\"  style\u003d\"font-size:large;\"\u003e\u003cspan class\u003d\"Apple-style-span\"  style\u003d\"color:#008080;\"\u003eSubscribe to the Alzheimer's Reading Room\u003c/span\u003e\u003c/span\u003e \u003cp\u003e\u003cb\u003eEnter Your Email Address\u003c/b\u003e  \u003cp\u003e\u003cinput name\u003d\"email\" style\u003d\"width: 200px;\" type\u003d\"text\" /\u003e\u003cinput name\u003d\"uri\" type\u003d\"hidden\" value\u003d\"TheAlzheimersReadingRoom\" /\u003e\u003cinput name\u003d\"loc\" type\u003d\"hidden\" value\u003d\"en_US\" /\u003e\u003cinput type\u003d\"submit\" value\u003d\"Subscribe\" /\u003e\u003c/p\u003e\u003c/form\u003e\u003ccenter\u003e\u003cb\u003eMore About the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/b\u003e\u003c/center\u003e \u003cb\u003e\u003cul\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/alzheimers-reading-room-testimonials.html\"\u003e60 Good Reasons to Subscribe to the Alzheimer's Reading Room \u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/advice-and-insight-alzheimers.html\"\u003eAlzheimer's CareGiving -- Insight and Advice\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/topic-test-your-memory-for-alzheimers.html\"\u003eTest Your Memory for Alzheimer's (5 Best Self Assessment Tests)\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/12/communicating-in-alzheimers-world.html\"\u003eCommunicating in  Alzheimer's World\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/11/worried-about-alzheimers-disease.html\"\u003eWorried About Alzheimer's Disease -- You Should Be\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/what-is-alzheimers-what-are-eight-types.html\"\u003eWhat is Alzheimer's? What are the Eight Types of Dementia?\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/does-combination-of-aricept-and-namenda.html\"\u003eDoes the Combination of Aricept and Namenda Help Slow the Rate of Decline in Alzheimer's Patients\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/alzheimers-statistics.html\"\u003eAlzheimer's Disease Statistics\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003cb\u003e\u003cb\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/03/is-it-really-alzheimers-or-something.html\"\u003eIs it Really Alzheimer's or Something Else?\u003c/a\u003e\u003c/b\u003e\u003c/b\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/05/ten-symptoms-of-early-stage-alzheimers.html\"\u003eTen Symptoms of Early Stage Alzheimer's\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/ten-tips-for-communicating-with.html\"\u003eTen Tips for Communicating with an Alzheimer’s Patient\u003c/a\u003e\u003c/li\u003e\u003c/ul\u003e\u003c/b\u003e  \u003ccenter\u003e\u003ctable\u003e\u003ctd align\u003dcenter\u003e \u003cimg src\u003d\"http://ws.amazon.com/widgets/q?MarketPlace\u003dUS\u0026amp;ServiceVersion\u003d20070822\u0026amp;ID\u003dAsinImage\u0026amp;WS\u003d1\u0026amp;Format\u003d_SL120_\u0026amp;ASIN\u003dB002KHMZQ8\u0026amp;tag\u003dalzreadingroom-20\" /\u003e\u003cbr /\u003e\u003ca href\u003d\"http://www.amazon.com/Alzheimers-Action-Plan-Diagnosis-Treatment/dp/B002KHMZQ8?ie\u003dUTF8\u0026tag\u003dalzreadingroom-20\"\u003e\u003cb\u003eThe Alzheimer's Action Plan\u003c/b\u003e\u003c/a\u003e \u003ctd width\u003d32\u003e \u0026nbsp; \u003ctd align\u003dcenter\u003e \u003cimg src\u003d\"http://ws.amazon.com/widgets/q?MarketPlace\u003dUS\u0026amp;ServiceVersion\u003d20070822\u0026amp;ID\u003dAsinImage\u0026amp;WS\u003d1\u0026amp;Format\u003d_SL120_\u0026amp;ASIN\u003d1932603166\u0026amp;tag\u003dalzreadingroom-20\" /\u003e\u003cbr /\u003e\u003ca href\u003d\"http://www.amazon.com/Caregivers-Guide-Alzheimers-Disease-Making/dp/1932603166?ie\u003dUTF8\u0026tag\u003dalzreadingroom-20\"\u003e\u003cb\u003e300 Tips for Making Life Easier\u003c/b\u003e\u003c/a\u003e\u003c/td\u003e\u003c/td\u003e\u003c/td\u003e\u003c/table\u003e\u003ccenter\u003e\u003c/center\u003e\u003c/center\u003e  \u003cblockquote\u003e\u003cdiv class\u003d\"separator\" style\u003d\"clear: both; text-align: left;\"\u003e\u003cimg border\u003d\"0\" height\u003d\"85\" src\u003d\"http://2.bp.blogspot.com/_UUEwElMfh90/SPDjt6cT4-I/AAAAAAAABMQ/MXL3uRljPQU/s200/Head+shot+5.JPG\"  style\u003d\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\" width\u003d\"85\" /\u003e\u003c/div\u003e\u003cspan style\u003d\"font-size: small;\"\u003e\u003cb\u003e\u003cb\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/09/bob-demarco-editorcontributor.html\"\u003eBob DeMarco\u003c/a\u003e\u003c/b\u003e\u003c/b\u003e\u003c/span\u003e\u003cb\u003e is the editor of the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e and an Alzheimer's caregiver. Bob has written more than 1,690 articles with more than 70,000 links on the Internet. Bob resides in Delray Beach, FL.\u003c/b\u003e  \u003c/blockquote\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: large;\"\u003eOriginal content Bob DeMarco, the \u003ca href\u003d\"http://www.alzheimersreadingroom.com\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/span\u003e\u003cdiv class\u003d\"blogger-post-footer\"\u003e\u003cimg width\u003d'1' height\u003d'1' src\u003d'https://blogger.googleusercontent.com/tracker/6471983413705881126-871743922858124897?l\u003dwww.alzheimersreadingroom.com' alt\u003d'' /\u003e\u003c/div\u003e"},"link":[{"rel":"related","href":"http://www.alzheimersreadingroom.com/2010/08/researchers-identify-key-target.html","title":"Researchers Identify Key Target Molecule for Alzheimer's Disease (ADAM10)"},{"rel":"replies","type":"application/atom+xml","href":"http://www.alzheimersreadingroom.com/feeds/871743922858124897/comments/default","title":"Post Comments"},{"rel":"replies","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/08/researchers-identify-key-target.html#comment-form","title":"0 Comments"},{"rel":"edit","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/871743922858124897"},{"rel":"self","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/871743922858124897"},{"rel":"alternate","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/08/researchers-identify-key-target.html","title":"Researchers Identify Key Target Molecule for Alzheimer's Disease (ADAM10)"}],"author":[{"name":{"$t":"Bob DeMarco"},"uri":{"$t":"http://www.blogger.com/profile/14861703129474871916"},"email":{"$t":"rtdemarco@gmail.com"},"gd$extendedProperty":{"xmlns$gd":"http://schemas.google.com/g/2005","name":"OpenSocialUserId","value":"02937219926706406775"}}],"media$thumbnail":{"xmlns$media":"http://search.yahoo.com/mrss/","url":"http://2.bp.blogspot.com/_UUEwElMfh90/SPDjt6cT4-I/AAAAAAAABMQ/MXL3uRljPQU/s72-c/Head+shot+5.JPG","height":"72","width":"72"},"thr$total":{"$t":"0"}},{"id":{"$t":"tag:blogger.com,1999:blog-6471983413705881126.post-5323482560930104332"},"published":{"$t":"2010-07-27T23:55:00.002-04:00"},"updated":{"$t":"2010-08-22T19:31:31.493-04:00"},"category":[{"scheme":"http://www.blogger.com/atom/ns#","term":"alzheimer's"},{"scheme":"http://www.blogger.com/atom/ns#","term":"pet"},{"scheme":"http://www.blogger.com/atom/ns#","term":"research"},{"scheme":"http://www.blogger.com/atom/ns#","term":"spinal tap"},{"scheme":"http://www.blogger.com/atom/ns#","term":"insurance"},{"scheme":"http://www.blogger.com/atom/ns#","term":"amyloid protein"}],"title":{"type":"text","$t":"Would You Want to Know if Alzheimer's was but a Few Years Away?"},"content":{"type":"html","$t":"\u003ci\u003e\u003cb\u003e\u003cspan style\u003d\"font-size: small;\"\u003eBy Max Wallack\u003c/span\u003e\u003c/b\u003e\u003c/i\u003e\u003cbr /\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: x-small;\"\u003e\u003cb\u003eAlzheimer's Reading Room\u003c/b\u003e\u003c/span\u003e\u003cbr /\u003e\u003cbr /\u003eToday I heard a short portion of a radio show on WBUR.  The first part was a discussion of what tests are currently available to diagnose whether a person is likely to have Alzheimer’s a few years down the line.\u003cbr /\u003e\u003cbr /\u003e\u003ca name\u003d'more'\u003e\u003c/a\u003e \u003cbr /\u003eI learned that there is a test done by Spinal Tap that can identify high levels of amyloid protein in the spinal fluid that would be indicative of future Alzheimer’s disease.  Also, a more sensitive test, a PET test, will soon be available for this purpose.\u003cbr /\u003e\u003cbr /\u003eOne question that several listeners called in to discuss was whether or not they would want to know that they would soon develop Alzheimer’s.  There were sensible answers on both sides of the question.\u003cbr /\u003e\u003cbr /\u003eOne teacher said that he has been teaching 30 years and is 59 years old.  If he knew he would have Alzheimer’s,  he would retire soon and spend his time traveling with his wife.  On the other hand, if he knew he was free from Alzheimer’s, he would work until 65 because he would feel he would most likely have lots of time for travel later.\u003cbr /\u003e\u003cbr /\u003eAnother man called in whose wife was 58.  She already had Alzheimer’s for many years.  He said he would not have wanted to know sooner.  He said it would have just made the family miserable that many years earlier, realizing what they were going to face.\u003cbr /\u003e\u003cbr /\u003eOne man said he would want to know because then he would make sure to live somewhere near a large research hospital where he could get the best care.  Several other people said they would want to know so they could make the best financial decisions.\u003cbr /\u003e\u003cbr /\u003eI think it is a difficult choice.  Knowing certainly does give a person more options and chances to make better decisions.  However, knowing probably does rob the person of additional years that could be spent free of Alzheimer’s and its problems, fears, and indignities.\u003cbr /\u003e\u003cbr /\u003eThere is also a question of insurance.  What insurance company would want to insure someone that was destined to have Alzheimer’s disease? \u003cbr /\u003e\u003cbr /\u003eWhat would you choose?  Would you want to know if Alzheimer’s was but a few years away? \u003cbr /\u003e\u003cblockquote\u003e\u003cdiv\u003e\u003cimg border\u003d\"0\" height\u003d\"100\" src\u003d\"http://1.bp.blogspot.com/_UUEwElMfh90/TBQW21902aI/AAAAAAAACPs/iKQZr06_VSw/s200/Max+Walack.jpg\" width\u003d\"95\" style\u003d\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\" width\u003d\"85\" /\u003e\u003c/div\u003e\u003cb\u003eMax Wallack\u003c/b\u003e is a student at Boston University Academy.  His great grandmother, Gertrude, suffered from Alzheimer's disease. Max is the founder of  \u003ca href\u003d\"http://www.puzzlestoremember.org/\"\u003e\u003cb\u003ePUZZLES TO REMEMBER.\u003c/b\u003e\u003c/a\u003e \u003cb\u003ePTR\u003c/b\u003e is a project that provides puzzles to nursing homes and veterans institutions that care for Alzheimer's and dementia patients.\u003c/blockquote\u003e\u003cbr /\u003e\u003cform action\u003d\"http://feedburner.google.com/fb/a/mailverify\" method\u003d\"post\" onsubmit\u003d\"window.open('http://feedburner.google.com/fb/a/mailverify?uri\u003dTheAlzheimersReadingRoom', 'popupwindow', 'scrollbars\u003dyes,width\u003d495,height\u003d468');return true\" style\u003d\"border: 1px solid #ccc; padding: 2 px; text-align: center;\" target\u003d\"popupwindow\"\u003e\u003cspan class\u003d\"Apple-style-span\"  style\u003d\"font-size:large;\"\u003e\u003cspan class\u003d\"Apple-style-span\"  style\u003d\"color:#008080;\"\u003eSubscribe to the Alzheimer's Reading Room\u003c/span\u003e\u003c/span\u003e \u003cp\u003e\u003cb\u003eEnter Your Email Address\u003c/b\u003e   \u003cinput name\u003d\"email\" style\u003d\"width: 200px;\" type\u003d\"text\" /\u003e\u003cinput name\u003d\"uri\" type\u003d\"hidden\" value\u003d\"TheAlzheimersReadingRoom\" /\u003e\u003cinput name\u003d\"loc\" type\u003d\"hidden\" value\u003d\"en_US\" /\u003e\u003cinput type\u003d\"submit\" value\u003d\"Subscribe\" /\u003e\u003c/p\u003e\u003c/form\u003e\u003ccenter\u003e\u003cb\u003eMore About the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/02/about-alzheimers-reading-room.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/b\u003e\u003c/center\u003e \u003cb\u003e\u003cul\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/alzheimers-reading-room-testimonials.html\"\u003e60 Good Reasons to Subscribe to the Alzheimer's Reading Room \u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/advice-and-insight-alzheimers.html\"\u003eAlzheimer's CareGiving -- Insight and Advice\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/topic-test-your-memory-for-alzheimers.html\"\u003eTest Your Memory for Alzheimer's (5 Best Self Assessment Tests)\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/12/communicating-in-alzheimers-world.html\"\u003eCommunicating in  Alzheimer's World\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/11/worried-about-alzheimers-disease.html\"\u003eWorried About Alzheimer's Disease -- You Should Be\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/what-is-alzheimers-what-are-eight-types.html\"\u003eWhat is Alzheimer's? What are the Eight Types of Dementia?\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/08/does-combination-of-aricept-and-namenda.html\"\u003eDoes the Combination of Aricept and Namenda Help Slow the Rate of Decline in Alzheimer's Patients\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/p/alzheimers-statistics.html\"\u003eAlzheimer's Disease Statistics\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003cb\u003e\u003cb\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2009/03/is-it-really-alzheimers-or-something.html\"\u003eIs it Really Alzheimer's or Something Else?\u003c/a\u003e\u003c/b\u003e\u003c/b\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/05/ten-symptoms-of-early-stage-alzheimers.html\"\u003eTen Symptoms of Early Stage Alzheimer's\u003c/a\u003e\u003c/li\u003e\u003cli\u003e\u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/03/ten-tips-for-communicating-with.html\"\u003eTen Tips for Communicating with an Alzheimer’s Patient\u003c/a\u003e\u003c/li\u003e\u003c/ul\u003e\u003c/b\u003e  \u003cbr /\u003e\u003ccenter\u003e\u003ctable\u003e\u003ctd align\u003dcenter\u003e \u003cimg src\u003d\"http://ws.amazon.com/widgets/q?MarketPlace\u003dUS\u0026amp;ServiceVersion\u003d20070822\u0026amp;ID\u003dAsinImage\u0026amp;WS\u003d1\u0026amp;Format\u003d_SL120_\u0026amp;ASIN\u003dB002KHMZQ8\u0026amp;tag\u003dalzreadingroom-20\" /\u003e\u003cbr /\u003e\u003ca href\u003d\"http://www.amazon.com/Alzheimers-Action-Plan-Diagnosis-Treatment/dp/B002KHMZQ8?ie\u003dUTF8\u0026tag\u003dalzreadingroom-20\"\u003e\u003cb\u003eThe Alzheimer's Action Plan\u003c/b\u003e\u003c/a\u003e \u003ctd width\u003d32\u003e \u0026nbsp; \u003ctd align\u003dcenter\u003e \u003cimg src\u003d\"http://ws.amazon.com/widgets/q?MarketPlace\u003dUS\u0026amp;ServiceVersion\u003d20070822\u0026amp;ID\u003dAsinImage\u0026amp;WS\u003d1\u0026amp;Format\u003d_SL120_\u0026amp;ASIN\u003d1932603166\u0026amp;tag\u003dalzreadingroom-20\" /\u003e\u003cbr /\u003e\u003ca href\u003d\"http://www.amazon.com/Caregivers-Guide-Alzheimers-Disease-Making/dp/1932603166?ie\u003dUTF8\u0026tag\u003dalzreadingroom-20\"\u003e\u003cb\u003e300 Tips for Making Life Easier\u003c/b\u003e\u003c/a\u003e\u003c/td\u003e\u003c/td\u003e\u003c/td\u003e\u003c/table\u003e\u003ccenter\u003e\u003c/center\u003e\u003c/center\u003e  \u003cbr /\u003e\u003cbr /\u003e\u003cspan class\u003d\"Apple-style-span\" style\u003d\"font-size: large;\"\u003eOriginal content Max Wallack, the \u003ca href\u003d\"http://www.alzheimersreadingroom.com/2010/07/would-you-want-to-know-if-alzheimers.html\"\u003eAlzheimer's Reading Room\u003c/a\u003e\u003c/span\u003e\u003cdiv class\u003d\"blogger-post-footer\"\u003e\u003cimg width\u003d'1' height\u003d'1' src\u003d'https://blogger.googleusercontent.com/tracker/6471983413705881126-5323482560930104332?l\u003dwww.alzheimersreadingroom.com' alt\u003d'' /\u003e\u003c/div\u003e"},"link":[{"rel":"related","href":"http://www.alzheimersreadingroom.com/2010/07/would-you-want-to-know-if-alzheimers.html","title":"Would You Want to Know if Alzheimer's was but a Few Years Away?"},{"rel":"replies","type":"application/atom+xml","href":"http://www.alzheimersreadingroom.com/feeds/5323482560930104332/comments/default","title":"Post Comments"},{"rel":"replies","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/07/would-you-want-to-know-if-alzheimers.html#comment-form","title":"0 Comments"},{"rel":"edit","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/5323482560930104332"},{"rel":"self","type":"application/atom+xml","href":"http://www.blogger.com/feeds/6471983413705881126/posts/default/5323482560930104332"},{"rel":"alternate","type":"text/html","href":"http://www.alzheimersreadingroom.com/2010/07/would-you-want-to-know-if-alzheimers.html","title":"Would You Want to Know if Alzheimer's was but a Few Years Away?"}],"author":[{"name":{"$t":"Max Wallack"},"uri":{"$t":"http://www.blogger.com/profile/03305111027278085174"},"email":{"$t":"noreply@blogger.com"},"gd$extendedProperty":{"xmlns$gd":"http://schemas.google.com/g/2005","name":"OpenSocialUserId","value":"13823163410178297648"}}],"media$thumbnail":{"xmlns$media":"http://search.yahoo.com/mrss/","url":"http://1.bp.blogspot.com/_UUEwElMfh90/TBQW21902aI/AAAAAAAACPs/iKQZr06_VSw/s72-c/Max+Walack.jpg","height":"72","width":"72"},"thr$total":{"$t":"0"}}]}});