Jan 7, 2012

Loneliness and Risk of Alzheimer Disease

Loneliness may put people at risk of an Alzheimer's like dementia.

Alzheimer's Reading Room

"People who described themselves as lonely were twice as likely to develop dementia," says researcher Robert Wilson of the Rush University Medical Center in Chicago.

Research suggests lonely people are at greater risk of developing dementia. Seniors who scored high on the loneliness quiz agreed with three or more of the following scenarios:
  • I experience a general sense of emptiness.
  • I miss having people around.
  • I feel like I don't have enough friends.
  • I often feel abandoned.I miss having really good friends.
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Loneliness and Risk of Alzheimer Disease

Robert S. Wilson
Context: Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood.

Objective: To test the hypothesis that loneliness is associated with increased risk of Alzheimer disease (AD).

Design: Longitudinal clinicopathologic cohort study with up to 4 years of annual in-home follow-up.

Participants: A total of 823 older persons free of dementia at enrollment were recruited from senior citizen facilities in and around Chicago, Ill. Loneliness was assessed with a 5-item scale at baseline (mean±SD, 2.3±0.6) and annually thereafter. At death, a uniform postmortem examination of the brain was conducted to quantify AD pathology in multiple brain regions and the presence of cerebral infarctions.

Main Outcome Measures: Clinical diagnosis of AD and change in previously established composite measures of global cognition and specific cognitive functions
Results: During follow-up, 76 subjects developed clinical AD. Risk of AD was more than doubled in lonely persons (score 3.2, 90th percentile) compared with persons who were not lonely (score 1.4, 10th percentile), and controlling for indicators of social isolation did not affect the finding. Loneliness was associated with lower level of cognition at baseline and with more rapid cognitive decline during follow-up. There was no significant change in loneliness, and mean degree of loneliness during the study was robustly associated with cognitive decline and development of AD. In 90 participants who died and in whom autopsy of the brain was performed, loneliness was unrelated to summary measures of AD pathology or to cerebral infarction.

Conclusion: Loneliness is associated with an increased risk of late-life dementia but not with its leading causes.

Arch Gen Psychiatry. 2007;64:234-240

Read the detailed research article here -- Loneliness and Risk of Alzheimer Disease

Robert S. Wilson, PhD; Kristin R. Krueger, PhD; Steven E. Arnold, MD; Julie A. Schneider, MD; Jeremiah F. Kelly, MD;
Lisa L. Barnes, PhD; Yuxiao Tang, PhD; David A. Bennett, MD

More Insight and Advice for Caregivers

Original content Bob DeMarco, the Alzheimer's Reading Room