Mar 15, 2018

Physically Fit Women Nearly 90 Percent Less Likely to Develop Dementia

Women with high physical fitness at middle age were nearly 90 percent less likely to develop dementia according to a new study.


Women with high physical fitness at middle age were nearly 90 percent less likely to develop dementia
by Alzheimer's Reading Room

The information in this study is significant.

An important finding of the study is that when highly fit women did develop dementia, they developed the disease an average of 11 years later than women who were moderately fit, or at age 90 instead of age 79.

Previous studies indicate that if the onset of Alzheimer's could be delayed to the age of 90, the number of people living with dementia would be cut in half.

Currently, at age 80 there is a thirty percent of being diagnosed with Alzheimer's disease.


There is no known treatment or cure for Alzheimer's. However there is a growing body of evidence that it is possible to "delay" the onset of Alzheimer's. This is what we should be focusing on right now.


This might sound harsh but you might die before you get to Stage 1 Alzheimer's. I think most of you will agree that we "wished" our loved one's had an extra 5 - 11 years of Alzheimer's free life.
  • Women with high physical fitness at middle age were nearly 90 percent less likely to develop dementia decades later, compared to women who were moderately fit.

From Rudy Tanzi - 6 Ways to Reduce Alzheimer's Risk and Keep Your Brain Healthy As You Age


The study measured the women’s cardiovascular fitness based on an exercise test.
  • When the highly fit women did develop dementia, they developed the disease an average of 11 years later than women who were moderately fit, or at age 90 instead of age 79.
“These findings are exciting because it’s possible that improving people’s cardiovascular fitness in middle age could delay or even prevent them from developing dementia,” said study author Helena Hörder, PhD, of the University of Gothenburg in Gothenburg, Sweden.
 “However, this study does not show cause and effect between cardiovascular fitness and dementia, it only shows an association. More research is needed to see if improved fitness could have a positive effect on the risk of dementia and also to look at when during a lifetime a high fitness level is most important.”

For the study, 191 women with an average age of 50 took a bicycle exercise test until they were exhausted to measure their peak cardiovascular capacity.

The average peak workload was measured at 103 watts.
  • A total of 40 women met the criteria for a high fitness level, or 120 watts or higher. 
  • A total of 92 women were in the medium fitness category; 
  • and, 59 women were in the low fitness category, defined as a peak workload of 80 watts or less, or having their exercise tests stopped because of high blood pressure, chest pain or other cardiovascular problems.
  • Over the next 44 years, the women were tested for dementia six times.

During that time, 44 of the women developed dementia.
  • Five percent of the highly fit women developed dementia, 
  • compared to 25 percent of moderately fit women 
  • and, 32 percent of the women with low fitness. 
  • The highly fit women were 88 percent less likely to develop dementia than the moderately fit women

  • Among the women who had to stop the exercise test due to problems, 45 percent developed dementia decades later.
“This indicates that negative cardiovascular processes may be happening in midlife that could increase the risk of dementia much later in life,” Hörder said.
Limitations of the study include the relatively small number of women involved, all of whom were from Sweden, so the results may not be applicable to other populations, Hörder said. Also, the women’s fitness level was measured only once, so any changes in fitness over time were not captured.


The study waspublished in the online issue of Neurology®, the medical journal of the American Academy of Neurology.

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The study was supported by the Swedish Forte Center on Aging and Health, the Swedish Research Council for Health, Working Life and Welfare, Alzheimer’s Association Stephanie B. Overstreet Scholars, Alzheimer’s Association Zenith Award, Sahlgrenska University Hospital, Bank of Sweden Tercentary Foundation, Swedish Brain Power and several Swedish foundations.

To learn more about dementia, visit www.aan.com/patients.

The American Academy of Neurology is the world's largest association of neurologists and neuroscience professionals, with 34,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care.

A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, stroke, migraine, multiple sclerosis, concussion, Parkinson's disease and epilepsy.

Citation
Helena Hörder, Lena Johansson, XinXin Guo, Gunnar Grimby, Silke Kern, Svante Östling, Ingmar Skoog. Midlife cardiovascular fitness and dementia. Neurology, 2018
DOI: 10.1212/WNL.0000000000005290