Feb 20, 2015

Diabetes and Depression Increase Dementia Risk in People

Diabetes and depression increase the risk of conversion to dementia.

By Alzheimer's Reading Room

Diabetes and Depression Increase Dementia Risk in People | Alzheimer's Reading Room

Results:
  1. Diabetes and prediabetes increased the risk of conversion from mild cognitive impairment (MCI) to Alzheimer’s dementia.
  2. Diabetes was also associated with increased risk of conversion from any-type of MCI to all cause dementia
  3. Metabolic syndrome and prediabetes predicted all-cause dementia in people with any type MCI. 
  4. Mediterranean diet decreased the risk of conversion to Alzheimer’s dementia. 
  5. The presence of neuropsychiatric symptoms predicted conversion from MCI dementia, but less formal education did not. 
  6. Depressive symptoms predicted conversion from MCI dementia in epidemiological but not clinical studies.

Conclusions:
  1. Diabetes increased the risk of conversion to dementia. 
  2. Other prognostic factors that are potentially manageable are
    • prediabetes and the metabolic syndrome,
    • neuropsychiatric symptoms,
    • and low dietary folate. 
  3. Dietary interventions and interventions to reduce neuropsychiatric symptoms, including depression, that increase risk of conversion to dementia may decrease new incidence of dementia.
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Diabetes and depression predict dementia risk in people with slowing minds
  • People with mild cognitive impairment are at higher risk of developing dementia if they have diabetes or psychiatric symptoms such as depression.
  • Mild cognitive impairment (MCI) is a state between normal ageing and dementia, where someone’s mind is functioning less well than would be expected for their age. 
  • It affects 19% of people aged 65 and over, and around 46% of people with MCI develop dementia within 3 years compared with 3% of the general population. 
The latest review paper, published in the American Journal of Psychiatry, analysed data from 62 separate studies, following a total of 15,950 people diagnosed with MCI. 
  • The study found that among people with MCI, those with diabetes were 65% more likely to progress to dementia and those with psychiatric symptoms were more than twice as likely to develop the condition. 
“There are strong links between mental and physical health, so keeping your body healthy can also help to keep your brain working properly,” explains lead author Dr Claudia Cooper (UCL Psychiatry). 
Lifestyle changes to improve diet and mood might help people with MCI to avoid dementia, and bring many other health benefits. This doesn't necessarily mean that addressing diabetes, psychiatric symptoms and diet will reduce an individual’s risk, but our review provides the best evidence to date about what might help.” 
 Confirming these findings and incorporating appropriate preventative strategies could play an important part in lessening the ever-increasing societal burden of dementia in our ageing population.

Professor Alan Thompson The Alzheimer’s Society charity recommends that people stay socially and physically active to help prevent dementia.

Their guidelines also suggest eating a diet high in fruit and vegetables and low in meat and saturated fats, such as the Mediterranean diet.
 “Some damage is already done in those with MCI but these results give a good idea about what it makes sense to target to reduce the chance of dementia,” says senior author Professor Gill Livingston (UCL Psychiatry). 
“Randomised controlled trials are now needed.” Professor Alan Thompson, Dean of the UCL Faculty of Brain Sciences, says:
“This impressive Systematic Review and meta-analysis from The Faculty of Brain Science’s Division of Psychiatry underlines two important messages.  
Firstly, the impact of medical and psychiatric co-morbidities in individuals with mild cognitive impairment and secondly, the importance and therapeutic potential of early intervention in the prevention of dementia.  
Confirming these findings and incorporating appropriate preventative strategies could play an important part in lessening the ever-increasing societal burden of dementia in our ageing population.” 
SourceModifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis



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